Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation (Q42171438)

17 October 2017

Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation (English)

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17 October 2017

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Fang Zhou

1

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17 October 2017

Jia-Yong Wu

2

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17 October 2017

Xiu-Lan Sun

3

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17 October 2017

Hong-Hong Yao

4

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17 October 2017

Jian-Hua Ding

5

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17 October 2017

Gang Hu

6

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17 October 2017

language of work or name

English

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publication date

14 March 2007

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17 October 2017

Neuropsychopharmacology

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17 October 2017

32

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17 October 2017

12

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17 October 2017

2570-2580

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https://scigraph.springernature.com/pub.10.1038/sj.npp.1301381

17 October 2017

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cites work

Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia

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7 January 2021

Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats

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7 January 2021

Mitochondrial K(ATP) channels in cell survival and death

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7 January 2021

Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration

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7 January 2021

Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.

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7 January 2021

Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

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7 January 2021

Pesticide-Parkinson link explored.

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7 January 2021

Targeting mitochondrial ATP-sensitive potassium channels--a novel approach to neuroprotection

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7 January 2021

CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice

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7 January 2021

A channel to neurodegeneration

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7 January 2021

Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain.

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7 January 2021

Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Novel anti-inflammatory therapy for Parkinson's disease.

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7 January 2021

Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives

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7 January 2021

Neuroscience. Pesticide causes Parkinson's in rats.

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons.

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Neuroinflammatory processes in Parkinson's disease

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

ATP-sensitive potassium channel opener iptakalim protected against the cytotoxicity of MPP+ on SH-SY5Y cells by decreasing extracellular glutamate level

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7 January 2021

Parkinson's disease, pesticides and mitochondrial dysfunction

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain

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7 January 2021

K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons

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7 January 2021

The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells

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7 January 2021

Inhibition of microglial inflammation by the MLK inhibitor CEP-1347.

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7 January 2021

Role of inflammation in neurodegenerative diseases

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7 January 2021

KATP channels as molecular sensors of cellular metabolism

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7 January 2021

Evidence for mitochondrial K+ channels and their role in cardioprotection

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7 January 2021

Reactive oxygen species as mediators of signal transduction in ischemic preconditioning

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

The rotenone model of Parkinson's disease.

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

ATP-sensitive potassium channels

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Selective microglial activation in the rat rotenone model of Parkinson's disease

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia.

1 reference

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7 January 2021

Targeting ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

New stereological methods for counting neurons

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Anti-proliferating effect of iptakalim, a novel KATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Neuroprotection by KATP channels.

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Mitochondrial ATP-sensitive potassium channel: a novel site for neuroprotection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Effects of iptakalim on rotenone-induced cytotoxicity and dopamine release from PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Systematic administration of iptakalim, an ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in rats

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats

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https://api.crossref.org/works/10.1038%2FSJ.NPP.1301381

7 January 2021

Identifiers

DOI

10.1038/SJ.NPP.1301381

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Dimensions Publication ID

17 October 2017

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