Structure of influenza A polymerase bound to the viral RNA promoter (Q42181164)

18 October 2017

Structure of influenza A polymerase bound to the viral RNA promoter (English)

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18 October 2017

Stephen Anthony Cusack

series ordinal

4

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18 October 2017

Stefan Reich

3

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Alexander Pflug

object named as

Alexander Pflug

series ordinal

1

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author name string

Delphine Guilligay

series ordinal

2

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PubMed ID

25409142

18 October 2017

language of work or name

English

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publication date

19 November 2014

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18 October 2017

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18 October 2017

516

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18 October 2017

355-360

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18 October 2017

7531

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https://scigraph.springernature.com/pub.10.1038/nature14008

18 October 2017

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cites work

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Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

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Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle

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Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

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The RNA polymerase of influenza virus, bound to the 5' end of virion RNA, acts in cis to polyadenylate mRNA.

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MolProbity: all-atom structure validation for macromolecular crystallography

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The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity

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The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

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Integration, scaling, space-group assignment and post-refinement

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12 December 2020

Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase

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The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes

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Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site

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12 December 2020

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

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12 December 2020

The influenza virus RNA synthesis machine: advances in its structure and function

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Influenza A virus polymerase is a site for adaptive changes during experimental evolution in bat cells

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12 December 2020

Mutagenic analysis of the 5' arm of the influenza A virus virion RNA promoter defines the sequence requirements for endonuclease activity

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12 December 2020

Evidence that the C-terminal PB2-binding region of the influenza A virus PB1 protein is a discrete alpha-helical domain

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12 December 2020

The RNA polymerase of influenza a virus: mechanisms of viral transcription and replication

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12 December 2020

Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure.

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12 December 2020

A mechanism for initiating RNA-dependent RNA polymerization

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12 December 2020

A new promoter-binding site in the PB1 subunit of the influenza A virus polymerase

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

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Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

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The structural basis for cap binding by influenza virus polymerase subunit PB2

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12 December 2020

Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis

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12 December 2020

Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue

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12 December 2020

Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae

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12 December 2020

Refinement of macromolecular structures by the maximum-likelihood method

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12 December 2020

The influenza virus panhandle is involved in the initiation of transcription

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12 December 2020

Multiprotein complex production in insect cells by using polyproteins.

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12 December 2020

A hairpin loop at the 5' end of influenza A virus virion RNA is required for synthesis of poly(A)+ mRNA in vitro

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12 December 2020

Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus

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Mutational analysis of influenza virus promoter elements in vivo

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12 December 2020

Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1

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Rift Valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerases

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A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases

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Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

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Promoter elements in the influenza vRNA terminal structure.

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Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2

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RNA-dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA-binding sites

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Sequence-specific binding of the influenza virus RNA polymerase to sequences located at the 5' ends of the viral RNAs.

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A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription

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New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain

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Characterization of the RNA-fork model of virion RNA in the initiation of transcription in influenza A virus

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12 December 2020

Characterization of influenza virus PB1 protein binding to viral RNA: two separate regions of the protein contribute to the interaction domain

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12 December 2020

Viral determinants of influenza A virus host range

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12 December 2020

Mutational analysis of the RNA-fork model of the influenza A virus vRNA promoter in vivo

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12 December 2020

A distinct lineage of influenza A virus from bats

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12 December 2020

Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase

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12 December 2020

A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs

1 reference

12 December 2020

Towards an atomic resolution understanding of the influenza virus replication machinery

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12 December 2020

A cluster of conserved basic amino acids near the C-terminus of the PB1 subunit of the influenza virus RNA polymerase is involved in the regulation of viral transcription

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12 December 2020

Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development

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12 December 2020

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

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12 December 2020

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE14008

1 reference

PubMed ID

25409142

Dimensions Publication ID

18 October 2017

0 references

1 reference

PubMed ID

25409142