Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α. (Q42185747)

18 October 2017

Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α. (English)

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18 October 2017

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Susan E Logue

3

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Ed C. Lavelle

object named as

Ed C Lavelle

10

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Seamus J. Martin

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Seamus J Martin

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author name string

Inna S Afonina

1

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18 October 2017

Graham A Tynan

2

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18 October 2017

Sean P Cullen

4

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18 October 2017

Michael Bots

5

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18 October 2017

Alexander U Lüthi

6

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18 October 2017

Emer P Reeves

7

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18 October 2017

Noel G McElvaney

8

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18 October 2017

Jan P Medema

9

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18 October 2017

1 October 2011

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18 October 2017

1 reference

18 October 2017

44

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18 October 2017

2

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18 October 2017

265-278

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Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.

18 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Human and mouse granzyme A induce a proinflammatory cytokine response.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

How dying cells alert the immune system to danger

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Human and murine granzyme B exhibit divergent substrate preferences

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Discordant regulation of granzyme H and granzyme B expression in human lymphocytes

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Biologic basis for interleukin-1 in disease

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Selective release of a processed form of interleukin 1 alpha

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Granzyme A is an interleukin 1 beta-converting enzyme

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Identification of a membrane-associated interleukin 1 in macrophages

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Localization of human mononuclear cell interleukin 1.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Determination of the minimum polypeptide lengths of the functionally active sites of human interleukins 1 alpha and 1 beta

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Structure-function mapping of interleukin 1 precursors. Cleavage leads to a conformational change in the mature protein

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Intracellular localization of human monocyte associated interleukin 1 (IL 1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Granule-associated serine proteases: granzymes might not just be killer proteases

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Cancer cell-derived IL-1alpha induces IL-8 release in endothelial cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

Granzyme B in Atherosclerosis and Transplant Vascular Disease: Association with Cell Death and Atherosclerotic Disease Severity

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319689

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor

17 August 2018

1 reference

12 December 2020

Aerosol α1 -antitrypsin treatment for cystic fibrosis

1 reference

12 December 2020

The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)

1 reference

12 December 2020

Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma

1 reference

12 December 2020

TAB1 modulates IL-1alpha mediated cytokine secretion but is dispensable for TAK1 activation

1 reference

12 December 2020

Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation

1 reference

12 December 2020

Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria

1 reference

12 December 2020

The identification of plant lectins with mucosal adjuvant activity

1 reference

12 December 2020

10.1016/J.MOLCEL.2011.07.037

Identifiers

DOI

1 reference

18 October 2017

1 reference

18 October 2017

PubMed publication ID

22017873

1 reference