Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol (Q42206028)

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scientific article published on December 1989

Language	Label	Description	Also known as
English	Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol	scientific article published on December 1989

Statements

scholarly article

1 reference

Europe PubMed Central

18 October 2017

Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol (English)

1 reference

Europe PubMed Central

18 October 2017

author name string

Iglesias J

1

1 reference

Europe PubMed Central

18 October 2017

Gibbons GF

2

1 reference

Europe PubMed Central

18 October 2017

language of work or name

0 references

publication date

1 December 1989

1 reference

Europe PubMed Central

18 October 2017

Biochemical Journal

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Europe PubMed Central

18 October 2017

264

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Europe PubMed Central

18 October 2017

2

1 reference

Europe PubMed Central

18 October 2017

495-502

1 reference

Europe PubMed Central

18 October 2017

Sterol Biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133607

26 October 2017

Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles.

1 reference

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26 October 2017

The metabolic route by which oleate is converted into cholesterol in rat hepatocytes

1 reference

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26 October 2017

Modulation of regulatory oxysterol formation and low density lipoprotein suppression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by ketoconazole. A role for cytochrome P-450 in the regulation of HMG-CoA reductase in rat int

1 reference

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26 October 2017

In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity.

1 reference

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26 October 2017

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols

1 reference

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26 October 2017

Regulation of cholesterol biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133607

26 October 2017

Short- and longer-term regulation of very-low-density lipoprotein secretion by insulin, dexamethasone and lipogenic substrates in cultured hepatocytes. A biphasic effect of insulin

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Specific accumulation of 17 alpha-hydroxyprogesterone in microsomal membranes during the process of cytochrome P-450(C-17)-catalysed androgen biosynthesis. A dynamic study of intermediate formation and turnover

1 reference

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26 October 2017

Biological activity of some oxygenated sterols

1 reference

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26 October 2017

Studies on the mechanism of lanosterol 14 α-demethylation. A requirement for two distinct types of mixed-function-oxidase systems

1 reference

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26 October 2017

Chemical and enzymic studies on the characterization of intermediates during the removal of the 14α-methyl group in cholesterol biosynthesis. The use of 32-functionalized lanostane derivatives

1 reference

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26 October 2017

The effect of carbon monoxide on the nature of the accumulated 4,4-dimethyl sterol precursors of cholesterol during its biosynthesis from (2-14C)mevalonic acid in vitro

1 reference

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29 May 2018

Inhibition of Sterol Synthesis in Cultured Mouse Cells by Cholesterol Derivatives Oxygenated in the Side Chain

1 reference

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29 May 2018

The metabolic sequence by which some 4,4-dimethyl sterols are converted into cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133607

29 May 2018

Effect of ketoconazole on cholesterol synthesis and on HMG-CoA reductase and LDL-receptor activities in Hep G2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133607

29 May 2018

Purification of oxysterol binding protein from hamster liver cytosol

1 reference

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29 May 2018

Cholesterol biosynthesis in preparations of liver from normal, fasting, x-irradiated, cholesterol-fed, triton, or delta 4-cholesten-3-one-treated rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133607

17 August 2018

Regulation of cholesterol biosynthesis in enucleated cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1133607

17 August 2018

Inhibition of Sterol Synthesis in Cultured Mouse Cells by 7α-Hydroxycholesterol, 7β-Hydroxycholesterol, and 7-Ketocholesterol

1 reference

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17 August 2018

The rôle of cytochrome P-450 in cholesterol biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lanosterol 14α-demethylase. The metabolism of some potential intermediates by cell-free systems from rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cholesterol biosynthesis in cultured cells by probable natural precursor sterols

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by oxysterol by-products of cholesterol biosynthesis. Possible mediators of low density lipoprotein action

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxysterol binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by azole antimycotics requires lanosterol demethylation, but not 24,25-epoxylanosterol formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of regulatory oxysterols, 32-oxolanosterol and 32-hydroxylanosterol in mevalonate-treated cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol metabolism during ketoconazole treatment in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative metabolism of cholesterol precursors: sensitivity to ketoconazole, an inhibitor of cytochrome P-450

1 reference

https://pubmed.ncbi.nlm.nih.gov/2604729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ2640495

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

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0 references

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