Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion (Q42206973)

18 October 2017

Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion (English)

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18 October 2017

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J Ferguson

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18 October 2017

I Arozarena

series ordinal

2

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18 October 2017

M Ehrhardt

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3

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18 October 2017

C Wellbrock

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4

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18 October 2017

language of work or name

English

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publication date

6 February 2012

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18 October 2017

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18 October 2017

32

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1

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18 October 2017

86-96

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describes a project that uses

18 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3378628/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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In melanoma, beta-catenin is a suppressor of invasion.

26 October 2017

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A phase 2 trial of dasatinib in advanced melanoma

26 October 2017

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26 October 2017

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Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

26 October 2017

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

26 October 2017

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26 October 2017

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MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.

26 October 2017

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Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways

26 October 2017

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Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer

26 October 2017

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Extracellular signal-regulated kinase promotes Rho-dependent focal adhesion formation by suppressing p190A RhoGAP.

26 October 2017

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BRAF as therapeutic target in melanoma

26 October 2017

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

26 October 2017

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FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST

26 October 2017

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Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma.

26 October 2017

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Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

26 October 2017

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Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

26 October 2017

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Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

26 October 2017

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Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells

26 October 2017

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Rac activation and inactivation control plasticity of tumor cell movement

26 October 2017

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mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src

26 October 2017

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Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines

26 October 2017

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Src and focal adhesion kinase as therapeutic targets in cancer

26 October 2017

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Cell motility through plasma membrane blebbing

26 October 2017

1 reference

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p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.

26 October 2017

1 reference

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Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

26 October 2017

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N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor

26 October 2017

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MT1-MMP: a key regulator of cell migration in tissue

26 October 2017

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Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases

26 October 2017

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Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.

26 October 2017

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The interplay between Src and integrins in normal and tumor biology

26 October 2017

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Isoform specific function of calpain 2 in regulating membrane protrusion

26 October 2017

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Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation

26 October 2017

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Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals

26 October 2017

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Cooperative roles of Fyn and cortactin in cell migration of metastatic murine melanoma

26 October 2017

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Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

26 October 2017

1 reference

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Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis

26 October 2017

1 reference

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Autocrine stimulation by osteopontin contributes to antiapoptotic signalling of melanocytes in dermal collagen

26 October 2017

1 reference

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Erk 1/2 differentially regulates the expression from the 1G/2G single nucleotide polymorphism in the MMP-1 promoter in melanoma cells

26 October 2017

1 reference

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ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378628

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.

26 October 2017

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Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function

26 October 2017

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Regulation of cell motility by mitogen-activated protein kinase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378628

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization

26 October 2017

1 reference

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Impact of the Src inhibitor saracatinib on the metastatic phenotype of a fibrosarcoma (KHT) tumor model.

26 October 2017

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Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells

29 May 2018

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A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

29 May 2018

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Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling.

17 August 2018

1 reference

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Activation of phosphatidylinositol 3-kinase by a complex of p59fyn and the receptor tyrosine kinase Xmrk is involved in malignant transformation of pigment cells

17 August 2018

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Crossref

https://api.crossref.org/works/10.1038%2FONC.2012.25

A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2012.25

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.25

1 reference

Dimensions Publication ID

18 October 2017

0 references

1 reference

18 October 2017

PubMed publication ID

22310287

1 reference