Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form (Q42221858)

18 October 2017

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form (English)

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18 October 2017

Adrian Creanga

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18 October 2017

Thomas D Glenn

2

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18 October 2017

Randall K Mann

3

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18 October 2017

Adam M Saunders

4

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18 October 2017

William S Talbot

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18 October 2017

Philip A Beachy

6

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18 October 2017

7 June 2012

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18 October 2017

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18 October 2017

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18 October 2017

1312-1325

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describes a project that uses

18 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3387659/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility

1 reference

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Mechanism and evolution of cytosolic Hedgehog signal transduction

26 October 2017

1 reference

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Hedgehog beyond medulloblastoma and basal cell carcinoma

26 October 2017

1 reference

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Evidence for a role of vertebrate Disp1 in long-range Shh signaling

26 October 2017

1 reference

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Hedgehog: functions and mechanisms

26 October 2017

1 reference

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Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1.

26 October 2017

1 reference

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Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

26 October 2017

1 reference

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High-resolution in situ hybridization to whole-mount zebrafish embryos

26 October 2017

1 reference

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Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

26 October 2017

1 reference

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Cholesterol modification restricts the spread of Shh gradient in the limb bud.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish

26 October 2017

1 reference

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Incredible journey: how do developmental signals travel through tissue?

26 October 2017

1 reference

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Tissue repair and stem cell renewal in carcinogenesis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones

26 October 2017

1 reference

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Novel lipid modifications of secreted protein signals

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Wnt proteins are lipid-modified and can act as stem cell growth factors

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Identification of a novel family of cell-surface proteins expressed in human vascular endothelium

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

A freely diffusible form of Sonic hedgehog mediates long-range signalling

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1).

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Identification of a palmitic acid-modified form of human Sonic hedgehog

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Cholesterol modification of hedgehog signaling proteins in animal development

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Stages of embryonic development of the zebrafish

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Sonic hedgehog shedding results in functional activation of the solubilized protein.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Lipoprotein-heparan sulfate interactions in the Hh pathway.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Scube2 mediates Hedgehog signalling in the zebrafish embryo

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Zebrafish smoothened functions in ventral neural tube specification and axon tract formation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Genetic analysis of fin formation in the zebrafish, Danio rerio

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387659

Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22677548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.191866.112

1 reference

release_warysvqpsvhjdphaukenz5zcoe

18 October 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/warysvqpsvhjdphaukenz5zcoe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

18 October 2017

1 reference