Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability. (Q42234345)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author

Christopher Mark Smales

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Shirley J Peters

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Alistair J Henry

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Paul E Stephens

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Shauna West

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

David P Humphreys

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

language of work or name

English

0 references

publication date

18 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

1 February 2020

published in

1 reference

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1 February 2020

volume

287

1 reference

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1 February 2020

issue

29

1 reference

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1 February 2020

page(s)

24525-24533

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

Comparative Effects of pH and Ionic Strength on Protein–Protein Interactions, Unfolding, and Aggregation for IgG1 Antibodies

1 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Stability of IgG isotypes in serum

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Design of therapeutic proteins with enhanced stability.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Immunoglobulin G4: an odd antibody

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Structural and functional characterization of disulfide isoforms of the human IgG2 subclass

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Human IgG2 antibodies display disulfide-mediated structural isoforms

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Isotype selection in antibody engineering

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Characterization of lower molecular weight artifact bands of recombinant monoclonal IgG1 antibodies on non-reducing SDS-PAGE.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Engineering stability into Escherichia coli secreted Fabs leads to increased functional expression

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Suppression of sodium dodecyl sulfate-polyacrylamide gel electrophoresis sample preparation artifacts for analysis of IgG4 half-antibody

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

26 October 2017

IgG4 breaking the rules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Flexibility of human IgG subclasses

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Intrachain disulfide bond in the core hinge region of human IgG4.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

A single amino acid substitution abolishes the heterogeneity of chimeric mouse/human (IgG4) antibody

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

The binding of human immunoglobulin G1 monomer and small, covalently cross-linked polymers of immunoglobulin G1 to human peripheral blood monocytes and polymorphonuclear leukocytes

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Structural studies of immunoglobulin G.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

26 October 2017

Human gamma-g subclasses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Acid-induced aggregation of human monoclonal IgG1 and IgG2: molecular mechanism and the effect of solution composition.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Influence of pH on Heat-Induced Aggregation and Degradation of Therapeutic Monoclonal Antibodies

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Disulfide connectivity of human immunoglobulin G2 structural isoforms

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

A broad range of Fab stabilities within a host of therapeutic IgGs.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

The inter-heavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Localisation of the monocyte-binding region on human immunoglobulin G.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397877

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.369744

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.369744

Contrasting IgG Structures Reveal Extreme Asymmetry and Flexibility

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.369744

Normal human immunoglobulin G4 is bispecific: it has two different antigen-combining sites

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22610095

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The effect of a point mutation on the stability of IgG4 as monitored by analytical ultracentrifugation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22610095

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22610095

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.369744

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610095%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

22610095

1 reference