SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure. (Q42255809)

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29 February 2020

title

SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure (English)

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29 February 2020

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4

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29 February 2020

Carlos G Santos-Gallego

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author name string

Lisa Tilemann

1

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29 February 2020

Ahyoung Lee

2

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29 February 2020

Kiyotake Ishikawa

3

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Kleopatra Rapti

5

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Erik Kohlbrenner

7

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Kenneth M Fish

8

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Changwon Kho

9

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Roger J Hajjar

10

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language of work or name

English

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publication date

1 November 2013

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Science Translational Medicine

29 February 2020

published in

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volume

5

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issue

211

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page(s)

211ra159

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Heart disease and stroke statistics--2012 update: a report from the American Heart Association

29 February 2020

cites work

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Molecular targets in heart failure gene therapy: current controversies and translational perspectives

21 January 2018

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Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies

21 January 2018

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Defective sumoylation pathway directs congenital heart disease

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Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction

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SUMO1-dependent modulation of SERCA2a in heart failure

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The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases

21 January 2018

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Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals

21 January 2018

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Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

21 January 2018

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Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

21 January 2018

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Adenovirus-associated virus vector-mediated gene transfer in hemophilia B

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CD8(+) T-cell responses to adeno-associated virus capsid in humans

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Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes

21 January 2018

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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

21 January 2018

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Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sites

21 January 2018

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Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes.

21 January 2018

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Dynamic regulation of sarcoplasmic reticulum Ca(2+) content and release by luminal Ca(2+)-sensitive leak in rat ventricular myocytes.

21 January 2018

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Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness

21 January 2018

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Constitutive cardiac overexpression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase delays myocardial failure after myocardial infarction in rats at a cost of increased acute arrhythmias

21 January 2018

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SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure

21 January 2018

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Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

21 January 2018

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Concomitant intravenous nitroglycerin with intracoronary delivery of AAV1.SERCA2a enhances gene transfer in porcine hearts

21 January 2018

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The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure

21 January 2018

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10.1126/SCITRANSLMED.3006487

21 January 2018

Identifiers

DOI

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29 February 2020

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