Physiologically based pharmacokinetic modelling of the three-step metabolism of pyrimidine using C-uracil as an in vivo probe (Q42283992)

19 October 2017

Physiologically based pharmacokinetic modelling of the three-step metabolism of pyrimidine using C-uracil as an in vivo probe (English)

1 reference

19 October 2017

1 reference

Suminobu Ito

1

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19 October 2017

Takeshi Kawamura

2

1 reference

19 October 2017

Makoto Inada

3

1 reference

19 October 2017

Yoshiharu Inoue

4

1 reference

19 October 2017

Yukihiro Hirao

5

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19 October 2017

Toshihisa Koga

6

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19 October 2017

Jun-ichi Kunizaki

7

1 reference

19 October 2017

Takefumi Shimizu

8

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19 October 2017

Hitoshi Sato

9

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19 October 2017

language of work or name

English

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publication date

1 December 2005

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British Journal of Clinical Pharmacology

19 October 2017

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19 October 2017

60

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19 October 2017

6

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19 October 2017

584-593

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Clinical implications of dihydropyrimidine dehydrogenase on 5-FU pharmacology

19 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

The role of pharmacogenetics and pharmacogenomics in cancer chemotherapy with 5-fluorouracil

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Novel oral fluoropyrimidines in the treatment of metastatic colorectal cancer.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Review article: urea breath tests for detecting Helicobacter pylori

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Perspectives in pharmacokinetics. Physiologically based pharmacokinetic modeling as a tool for drug development

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Degradation of pyrimidines and pyrimidine analogs--pathways and mutual influences

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Dihydropyrimidine dehydrogenase deficiency leading to thymine-uraciluria. An inborn error of pyrimidine metabolism

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Fluorouracil: biochemistry and pharmacology

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Clinical pharmacology of 5-fluorouracil

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Metabolism of pyrimidine analogues and their nucleosides

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Physiological pharmacokinetics of a new muscle-relaxant, inaperisone, combined with its pharmacological effect on blood flow rate

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Receptor-recycling model of clearance and distribution of insulin in the perfused mouse liver

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Population and family studies of dihydropyrimidinuria: prevalence, inheritance mode, and risk of fluorouracil toxicity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Steady-state nonlinear pharmacokinetics of 5-fluorouracil during hepatic arterial and intravenous infusions in cancer patients.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Physiologically based pharmacokinetics of radioiodinated human beta-endorphin in rats. An application of the capillary membrane-limited model.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Metabolic fate of pyrimidines and purines in dietary nucleic acids ingested by mice

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Relationships among plasma [2-(13)C]uracil concentrations, breath (13)CO(2) expiration, and dihydropyrimidine dehydrogenase (DPD) activity in the liver in normal and dpd-deficient dogs

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Influence of cisapride on gastric emptying of solids and liquids monitored by 13C breath tests.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884889

Dihydrouracil dehydrogenase of rat liver. Separation of hydrogenase and dehydrogenase activities

17 August 2018

1 reference

12 December 2020

Combination clinical trials with thymidine and fluorouracil: a phase I and clinical pharmacologic evaluation

1 reference

12 December 2020

Nonlinear pharmacokinetic models for 5-fluorouracil in man: intravenous and intraperitoneal routes

1 reference

12 December 2020

Elevated urine, blood and cerebrospinal fluid levels of uracil and thymine in a child with dihydrothymine dehydrogenase deficiency

1 reference

12 December 2020

Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells

1 reference

12 December 2020

Dihydropyrimidine dehydrogenase deficiency--a further case

1 reference

12 December 2020

Campylobacter pylori detected noninvasively by the 13C-urea breath test

1 reference

12 December 2020

Severe 5-fluorouracil toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity

1 reference

12 December 2020

Evaluation of the 13CO2 kinetics in humans after oral application of sodium bicarbonate as a model for breath testing

1 reference

12 December 2020

Combined carbon-13-glycine/carbon-14-octanoic acid breath test to monitor gastric emptying rates of liquids and solids

1 reference

12 December 2020

Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection

1 reference

12 December 2020

Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs

1 reference

12 December 2020

[13C]octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy

1 reference

12 December 2020

A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs

1 reference

12 December 2020

Use of a [13C]urea breath test for detection of gastric infection with Helicobacter spp in dogs

1 reference

12 December 2020

Pyrimidine metabolism. I. Enzymatic pathways of uracil and thymine degradation

1 reference

12 December 2020

The catabolism of C14-labeled uracil, dihydrouracil, and beta-ureidopropionic acid in rat liver slices

1 reference

12 December 2020

10.1111/J.1365-2125.2005.02472.X

Identifiers

DOI

1 reference

19 October 2017

1 reference

19 October 2017

PubMed publication ID

16305582

1 reference