What lies behind serum urate concentration? Insights from genetic and genomic studies (Q42284423)

19 October 2017

1 reference

title

What lies behind serum urate concentration? Insights from genetic and genomic studies (English)

1 reference

19 October 2017

Kimiyoshi Ichida

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19 October 2017

29 December 2009

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19 October 2017

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19 October 2017

1

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19 October 2017

12

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19 October 2017

118

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https://scigraph.springernature.com/pub.10.1186/gm118

19 October 2017

0 references

cites work

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Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

26 October 2017

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Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

26 October 2017

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26 October 2017

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Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states

26 October 2017

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Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia

26 October 2017

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Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha

26 October 2017

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SLC2A9 is a high-capacity urate transporter in humans

26 October 2017

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Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

26 October 2017

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Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish

26 October 2017

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The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population

26 October 2017

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Age and origin of the G774A mutation in SLC22A12 causing renal hypouricemia in Japanese

26 October 2017

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Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)

26 October 2017

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Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study

26 October 2017

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SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

26 October 2017

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SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

26 October 2017

1 reference

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The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts

26 October 2017

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The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.

26 October 2017

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

26 October 2017

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New insights into renal transport of urate.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Human renal organic anion transporter 4 operates as an asymmetric urate transporter

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

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26 October 2017

1 reference

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Uric acid and hypertension

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Role of the breast cancer resistance protein (ABCG2) in drug transport

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Human Organic Anion Transporter 3 (hOAT3) can Operate as an Exchanger and Mediate Secretory Urate Flux

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

PDZK1: I. a major scaffolder in brush borders of proximal tubular cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Urate transport via human PAH transporter hOAT1 and its gene structure

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Molecular identification of a renal urate anion exchanger that regulates blood urate levels

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Molecular aspects of renal anionic drug transport

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Indirect coupling between sodium and urate transport in the proximal tubule

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Effect of insulin on uric acid excretion in humans.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Allelism of MCKD, FJHN and GCKD caused by impairment of uromodulin export dynamics

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

The potential role of adenosine in the pathophysiology of the insulin resistance syndrome

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808734

British Society for Rheumatology and British Health Professionals in Rheumatology Guideline for the Management of Gout

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20090896

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Indirect coupling of urate and p-aminohippurate transport to sodium in human brush-border membrane vesicles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20090896

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/GM118

1 reference

PMCID

2808734

Dimensions Publication ID

19 October 2017

0 references

1 reference

19 October 2017

1 reference

PMCID

2808734