Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening (Q42376445)

28 October 2017

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening (English)

1 reference

28 October 2017

2

1 reference

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1 June 2020

Celeste M Karch

11

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1 June 2020

author name string

Chao Wang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28966121%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Robert Chen

3

1 reference

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1 June 2020

Kai Liu

4

1 reference

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1 June 2020

Tara E Tracy

5

1 reference

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1 June 2020

Xu Chen

6

1 reference

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1 June 2020

Min Xie

7

1 reference

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1 June 2020

Peter Dongmin Sohn

8

1 reference

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1 June 2020

Connor Ludwig

9

1 reference

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1 June 2020

Anke Meyer-Franke

10

1 reference

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1 June 2020

Sheng Ding

12

1 reference

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1 June 2020

Li Gan

13

1 reference

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1 June 2020

publication date

26 September 2017

1 reference

28 October 2017

1 reference

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1 June 2020

volume

9

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1 June 2020

issue

4

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1 June 2020

page(s)

1221-1233

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Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model

1 June 2020

cites work

1 reference

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The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain

28 May 2018

1 reference

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Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.

28 May 2018

1 reference

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Tau in physiology and pathology

28 May 2018

1 reference

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

28 May 2018

1 reference

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Neuroanatomy and pathology of sporadic Alzheimer's disease

28 May 2018

1 reference

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A facile method for simultaneously measuring neuronal cell viability and neurite outgrowth

28 May 2018

1 reference

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Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation

28 May 2018

1 reference

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Transcription activator-like effector nuclease (TALEN)-mediated CLYBL targeting enables enhanced transgene expression and one-step generation of dual reporter human induced pluripotent stem cell (iPSC) and neural stem cell (NSC) lines

28 May 2018

1 reference

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Rapid neurogenesis through transcriptional activation in human stem cells.

28 May 2018

1 reference

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Invited review: Drug development for tauopathies

28 May 2018

1 reference

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Generation of induced neuronal cells by the single reprogramming factor ASCL1

28 May 2018

1 reference

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Comparison and optimization of hiPSC forebrain cortical differentiation protocols

28 May 2018

1 reference

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Administration of a selective β2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's disease

28 May 2018

1 reference

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Genetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies

28 May 2018

1 reference

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Isolation of single-base genome-edited human iPS cells without antibiotic selection

28 May 2018

1 reference

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Development-inspired reprogramming of the mammalian central nervous system

28 May 2018

1 reference

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Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease

28 May 2018

1 reference

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A high-throughput screening assay for determining cellular levels of total tau protein

28 May 2018

1 reference

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Antisense reduction of tau in adult mice protects against seizures

28 May 2018

1 reference

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Rapid single-step induction of functional neurons from human pluripotent stem cells

28 May 2018

1 reference

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Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.

28 May 2018

1 reference

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Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.

28 May 2018

1 reference

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Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos

28 May 2018

1 reference

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Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

28 May 2018

1 reference

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Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice

28 May 2018

1 reference

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Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice

28 May 2018

1 reference

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Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

28 May 2018

1 reference

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Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

28 May 2018

1 reference

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High content screening in neurodegenerative diseases

28 May 2018

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Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes.

28 May 2018

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Are tangles as toxic as they look?

28 May 2018

1 reference

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Induction of human neuronal cells by defined transcription factors

28 May 2018

1 reference

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Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

28 May 2018

1 reference

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Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice

28 May 2018

1 reference

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Tau reduction prevents Abeta-induced defects in axonal transport.

28 May 2018

1 reference

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

28 May 2018

1 reference

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Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia.

28 May 2018

1 reference

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Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

28 May 2018

1 reference

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Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments

28 May 2018

1 reference

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

28 May 2018

1 reference

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The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

28 May 2018

1 reference

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Robust statistical methods for hit selection in RNA interference high-throughput screening experiments

28 May 2018

1 reference

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Tau suppression in a neurodegenerative mouse model improves memory function

28 May 2018

1 reference

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High throughput screening of beta-amyloid secretion inhibitors using homogenous time-resolved fluorescence

28 May 2018

1 reference

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Improved statistical methods for hit selection in high-throughput screening

28 May 2018

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

28 May 2018

1 reference

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Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Characterization of tau proteins in human neuroblastoma SH-SY5Y cell line.

28 May 2018

1 reference

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Isoproterenol regulates tumour necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Norepinephrine inhibits gamma-interferon-induced major histocompatibility class II (Ia) antigen expression on cultured astrocytes via beta-2-adrenergic signal transduction mechanisms

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Loss of high-affinity alpha 2-adrenoceptors in Alzheimer's disease: an autoradiographic study in frontal cortex and hippocampus

28 May 2018

1 reference

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Tau-based therapeutics for Alzheimer's disease: active and passive immunotherapy.

28 May 2018

1 reference

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Development of a Scalable, High-Throughput-Compatible Assay to Detect Tau Aggregates Using iPSC-Derived Cortical Neurons Maintained in a Three-Dimensional Culture Format

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Use of high content image analyses to detect chemical-mediated effects on neurite sub-populations in primary rat cortical neurons.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Association of an extended haplotype in the tau gene with progressive supranuclear palsy

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639430

Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28966121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STEMCR.2017.08.019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28966121%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28966121%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

28966121

1 reference