Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis. (Q42411930)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17673911%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis (English)

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3 January 2020

1

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3 January 2020

Andrei I Tarasov

2

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3 January 2020

Tim J Craig

3

1 reference

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3 January 2020

Mark S.P. Sansom

4

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3 January 2020

author name string

Frances M Ashcroft

5

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3 January 2020

language of work or name

English

0 references

publication date

2 August 2007

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3 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17673911%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

volume

26

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3 January 2020

issue

16

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3 January 2020

page(s)

3749-3759

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describes a project that uses

3 January 2020

1 reference

Modeling, docking, and simulation of the major facilitator superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

28 May 2018

From molecule to malady

1 reference

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Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels

28 May 2018

1 reference

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Molecular simulations and lipid-protein interactions: potassium channels and other membrane proteins

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.

28 May 2018

1 reference

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28 May 2018

1 reference

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ATP-sensitive potassium channelopathies: focus on insulin secretion

28 May 2018

1 reference

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Regulation of the ATP-sensitive K channel Kir6.2 by ATP and PIP(2).

28 May 2018

1 reference

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Focus on Kir6.2: a key component of the ATP-sensitive potassium channel

28 May 2018

1 reference

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Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.

28 May 2018

1 reference

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Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Detection, delineation, measurement and display of cavities in macromolecular structures

28 May 2018

1 reference

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Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2

28 May 2018

1 reference

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Multiple sequence alignment with the Clustal series of programs

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Crystal structure of the potassium channel KirBac1.1 in the closed state

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Specificity of activation by phosphoinositides determines lipid regulation of Kir channels

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Structural and functional determinants of conserved lipid interaction domains of inward rectifying Kir6.2 channels

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Setting up and optimization of membrane protein simulations.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Nucleotides and phospholipids compete for binding to the C terminus of KATP channels

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Comparative protein structure modeling. Introduction and practical examples with modeller.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Homology modeling and molecular dynamics simulation studies of an inward rectifier potassium channel

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

PIP2 and PIP as determinants for ATP inhibition of KATP channels

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Membrane phospholipid control of nucleotide sensitivity of KATP channels

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Anionic phospholipids activate ATP-sensitive potassium channels

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

VMD: visual molecular dynamics

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Automated docking of flexible ligands: applications of AutoDock

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Direct modulation of Kir channel gating by membrane phosphatidylinositol 4,5-bisphosphate

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

The C42R mutation in the Kir6.2 (KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Phosphatidylinositol 4,5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminus

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Compromised ATP binding as a mechanism of phosphoinositide modulation of ATP-sensitive K+ channels

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Phospholipids as modulators of K(ATP) channels: distinct mechanisms for control of sensitivity to sulphonylureas, K(+) channel openers, and ATP.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1952224

Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17673911

12 December 2020

inferred from PubMed ID database lookup

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17673911

12 December 2020

inferred from PubMed ID database lookup

Molecular dynamics with coupling to an external bath

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601809

7 January 2021

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601809

7 January 2021

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601809

7 January 2021

GROMACS 3.0: a package for molecular simulation and trajectory analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601809

7 January 2021

Identifiers

DOI

10.1038/SJ.EMBOJ.7601809

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17673911%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17673911%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference