Nanomolar inhibitors of the transcription factor STAT5b with high selectivity over STAT5a (Q42425813)

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1 March 2020

title

Nanomolar inhibitors of the transcription factor STAT5b with high selectivity over STAT5a (English)

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1 March 2020

3

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1 March 2020

author name string

Nagarajan Elumalai

1

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1 March 2020

Angela Berg

2

1 reference

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1 March 2020

Andrej Scharow

4

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1 March 2020

Thorsten Berg

5

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1 March 2020

language of work or name

English

0 references

publication date

20 February 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25702814%20AND%20SRC:MED&resulttype=core&format=json

Angewandte Chemie International Edition

1 March 2020

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

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1 March 2020

volume

54

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1 March 2020

issue

16

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1 March 2020

page(s)

4758-4763

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25702814%20AND%20SRC:MED&resulttype=core&format=json

BCR-ABL affects STAT5A and STAT5B differentially

1 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

STAT5b deficiency: lessons from STAT5b gene mutations

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

In vivo identification of novel STAT5 target genes

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

A high-throughput assay for signal transducer and activator of transcription 5b based on fluorescence polarization

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Structure of the unphosphorylated STAT5a dimer

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Constitutive activation of Stat5b contributes to carcinogenesis in vivo

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Searching for specificity in SH domains

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Modular peptide recognition domains in eukaryotic signaling

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471549

Progress towards the development of SH2 domain inhibitors

16 August 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201410672

Discovery of chromone-based inhibitors of the transcription factor STAT5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201410672

A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201410672

Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201410672

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201410672

Transcription factors as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201410672

The STATs of cancer--new molecular targets come of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201410672

Signal transducers and activators of transcription as targets for small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201410672

Comparative study on the phosphotyrosine motifs of different cytokine receptors involved in STAT5 activation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25702814

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/ANIE.201410672

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25702814%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25702814%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

25702814

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25702814%20AND%20SRC:MED&resulttype=core&format=json