Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells (Q42446777)

31 October 2017

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells (English)

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chronic lymphocytic leukemia

31 October 2017

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8

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31 October 2017

V Berno

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author name string

S Gobessi

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31 October 2017

L Laurenti

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31 October 2017

P G Longo

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31 October 2017

L Carsetti

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31 October 2017

S Sica

6

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31 October 2017

G Leone

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31 October 2017

18 December 2008

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31 October 2017

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31 October 2017

23

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31 October 2017

4

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31 October 2017

686-697

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https://scigraph.springernature.com/pub.10.1038/leu.2008.346

31 October 2017

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cites work

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Chronic lymphocytic leukemia: revelations from the B-cell receptor.

21 January 2018

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The B-cell receptor and ZAP-70 in chronic lymphocytic leukemia

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Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

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Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

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Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

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ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

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ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

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Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

ITAM-mediated tonic signalling through pre-BCR and BCR complexes

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Regulation of B-cell fate by antigen-receptor signals

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

21 January 2018

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Syk-dependent mTOR activation in follicular lymphoma cells.

21 January 2018

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Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Activation of the Wnt signaling pathway in chronic lymphocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

The triterpenoid CDDO induces apoptosis in refractory CLL B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

Immunotoxicity assessment for the novel Spleen tyrosine kinase inhibitor R406.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

Mechanisms of B-cell lymphoma pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

7 January 2021

Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

7 January 2021

Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

7 January 2021

Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells

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https://api.crossref.org/works/10.1038%2FLEU.2008.346

7 January 2021

Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

7 January 2021

AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.346

7 January 2021

Identifiers

DOI

10.1038/LEU.2008.346

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Dimensions Publication ID

31 October 2017

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