The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism (Q42490911)

1 November 2017

The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism (English)

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1 November 2017

Shino Nemoto

1

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1 November 2017

Christian A Combs

2

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1 November 2017

Stephanie French

3

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1 November 2017

Bong-Hyun Ahn

4

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1 November 2017

Maria M Fergusson

5

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1 November 2017

Robert S Balaban

6

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1 November 2017

Toren Finkel

7

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1 November 2017

language of work or name

English

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publication date

14 February 2006

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Journal of Biological Chemistry

1 November 2017

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1 November 2017

281

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1 November 2017

15

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1 November 2017

10555-10560

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Oxidants, oxidative stress and the biology of ageing

1 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

Mitochondria, oxidants, and aging

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

DAF-16 target genes that control C. elegans life-span and metabolism.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

A systematic RNAi screen for longevity genes in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

A metabolic model for life span determination in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

The plasticity of aging: insights from long-lived mutants

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511626200

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

Deletion of p66shc gene protects against age-related endothelial dysfunction

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511626200

Direct imaging of dehydrogenase activity within living cells using enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP)

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M511626200

NADH enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP): applications to enzyme and mitochondrial reaction kinetics, in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511626200

Enzyme-dependent fluorescence recovery after photobleaching of NADH: in vivo and in vitro applications to the study of enzyme kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511626200

A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511626200

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511626200

Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511626200

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M511626200

21 January 2018

Identifiers

DOI

10.1074/JBC.M511626200

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1 November 2017

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