Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein (Q42493384)

1 November 2017

title

Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein (English)

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1 November 2017

C Brimer

1

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1 November 2017

J T Dalton

2

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1 November 2017

Z Zhu

3

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1 November 2017

J Schuetz

4

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1 November 2017

K Yasuda

5

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1 November 2017

E Vanin

6

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1 November 2017

M V Relling

7

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1 November 2017

Y Lu

8

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1 November 2017

E G Schuetz

9

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1 November 2017

language of work or name

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1 July 2000

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1 November 2017

published in

Pharmaceutical Research

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1 November 2017

volume

17

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1 November 2017

issue

7

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1 November 2017

page(s)

803-810

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Therapeutic gene targeting

1 November 2017

cites work

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CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts.

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Structure of adenovirus complexed with its internalization receptor, alphavbeta5 integrin

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Adenovirus-mediated expresssion of the murine ecotropic receptor facilitates transduction of human hematopoietic cells with an ecotropic retroviral vector.

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Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase

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12 December 2020

Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line

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12 December 2020

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

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12 December 2020

The levels of integrin alpha v beta 5 may predict the susceptibility to adenovirus-mediated gene transfer in human lung cancer cells

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12 December 2020

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells

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12 December 2020

Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes

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12 December 2020

Manipulation of adenovirus vectors

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12 December 2020

Stable expression of human cytochrome P450 3A4 in conjunction with human NADPH-cytochrome P450 oxidoreductase in V79 Chinese hamster cells.

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A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

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O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.

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12 December 2020

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

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12 December 2020

Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

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12 December 2020

Efficient transfer of genes into senescent cells by adenovirus vectors via highly expressed alpha v beta 5 integrin

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Role of integrin expression in adenovirus-mediated gene delivery to the intestinal epithelium

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P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

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12 December 2020

Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein

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12 December 2020

CYP3A4 expressed by insect cells infected with a recombinant baculovirus containing both CYP3A4 and human NADPH-cytochrome P450 reductase is catalytically similar to human liver microsomal CYP3A4.

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First-pass metabolism of cyclosporin by the gut

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Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

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Adenoviral transduction efficiency partly correlates with expression levels of integrin alphavbeta5, but not alphavbeta3 in human gastric carcinoma cells.

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12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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12 December 2020

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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12 December 2020

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

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12 December 2020

Identifiers

DOI

10.1023/A:1007599923694

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1 November 2017

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