Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. (Q42495060)

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English	Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.	scientific article

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1 November 2019

Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus (English)

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1 November 2019

subthalamic nucleus

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H Awad

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G W Hubert

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1 November 2019

Y Smith

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A I Levey

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P J Conn

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1 November 2000

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1 November 2019

Journal of Neuroscience

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1 November 2019

20

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1 November 2019

21

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1 November 2019

7871-7879

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1 November 2019

The functional anatomy of basal ganglia disorders

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CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding

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Metabotropic glutamate agonist-induced rotation: a pharmacological, FOS immunohistochemical, and [14C]-2-deoxyglucose autoradiographic study.

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Heterogeneity of metabotropic glutamate receptors in the striatum: electrophysiological evidence

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Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

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Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys

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Subthalamotomy in parkinsonian monkeys. Behavioural and biochemical analysis.

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Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones

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Differential loss of striatal projection neurons in Huntington disease

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Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity

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Pharmacology and functions of metabotropic glutamate receptors

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Reversal of experimental parkinsonism by lesions of the subthalamic nucleus

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Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus

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3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus

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Activation of group II metabotropic glutamate receptors inhibits synaptic excitation of the substantia Nigra pars reticulata

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Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat.

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Intrastriatal and intrasubthalamic stimulation of metabotropic glutamate receptors: A behavioral and Fos immunohistochemical study

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Striatal and nigral neuron subpopulations in rigid Huntington's disease: implications for the functional anatomy of chorea and rigidity-akinesia

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Subthalamic nucleus neurons switch from single-spike activity to burst-firing mode.

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Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

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Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

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Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain.

1 reference

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Glutamate metabotropic receptors increase a Ca(2+)-activated nonspecific cationic current in CA1 hippocampal neurons

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Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain

1 reference

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Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons.

1 reference

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1 reference

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Switch from facilitation to inhibition of excitatory synaptic transmission by group I mGluR desensitization

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G protein-coupled receptors mediate a fast excitatory postsynaptic current in CA3 pyramidal neurons in hippocampal slices

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Metabotropic glutamate receptor 5 is a disulfide-linked dimer

1 reference

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1 reference

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1 reference

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based on heuristic

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Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation

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12 December 2020

based on heuristic

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Immunohistochemical localization of metabotropic glutamate receptors mGluR1a and mGluR2/3 in the rat basal ganglia

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based on heuristic

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Identifiers

10.1523/JNEUROSCI.20-21-07871.2000

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1 November 2019

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1 November 2019

PubMed publication ID

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