Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis. (Q42516435)

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2 January 2020

title

Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis (English)

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2 January 2020

3

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2 January 2020

Nico Mitro

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2 January 2020

Elena Scotti

4

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2 January 2020

Federica Gilardi

6

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2 January 2020

Maurizio Crestani

9

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2 January 2020

author name string

Cristina Godio

2

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2 January 2020

Andrea Galmozzi

5

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2 January 2020

Donatella Caruso

7

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2 January 2020

Ana Belen Vigil Chacon

8

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language of work or name

English

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publication date

1 September 2007

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2 January 2020

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2 January 2020

volume

46

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issue

3

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2 January 2020

page(s)

885-897

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Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

2 January 2020

cites work

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Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors

21 January 2018

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21 January 2018

Bile acid biosynthesis

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7 January 2021

Bile acid synthesis from cholesterol: regulatory and auxiliary pathways

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7 January 2021

Nuclear orphan receptors control cholesterol catabolism.

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7 January 2021

Identification of a nuclear receptor for bile acids

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7 January 2021

Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription

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7 January 2021

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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7 January 2021

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

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7 January 2021

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

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7 January 2021

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

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7 January 2021

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by

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7 January 2021

Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle

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7 January 2021

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

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7 January 2021

Redundant pathways for negative feedback regulation of bile acid production

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7 January 2021

Perspectives in cholesterol-lowering therapy: the role of ezetimibe, a new selective inhibitor of intestinal cholesterol absorption

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7 January 2021

Familial hypercholesterolemia (one form of familial type II hyperlipoproteinemia). A study of its biochemical, genetic and clinical presentation in childhood

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7 January 2021

Overexpression of cholesterol 7alpha-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene. LDL transport and plasma LDL concentrations are reduced

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7 January 2021

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

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A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells

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Regulation of fecal bile acid excretion in male golden Syrian hamsters fed a cereal-based diet with and without added cholesterol

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7 January 2021

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

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7 January 2021

Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits

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7 January 2021

Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7

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7 January 2021

Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins

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7 January 2021

Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.

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7 January 2021

Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression

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7 January 2021

Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism

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7 January 2021

Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

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7 January 2021

The effect of chronic anticonvulsant therapy on serum lipids and lipoproteins in epileptic children

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7 January 2021

Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy

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7 January 2021

Serum lipids, lipoproteins and apolipoproteins A and B in epileptic patients treated with valproic acid, carbamazepine or phenobarbital

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7 January 2021