Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats (Q42520178)

1 November 2017

title

Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats (English)

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1 November 2017

Niho N

1

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Shibutani M

2

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Toyoda K

3

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Sato H

4

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Hirose A

5

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Imaida K

6

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Takahashi M

7

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Hayashi Y

8

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Hirose M

9

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1 November 2017

publication date

1 May 2002

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Food and Chemical Toxicology

1 November 2017

published in

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1 November 2017

volume

40

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1 November 2017

issue

5

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1 November 2017

page(s)

715-722

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The carcinogenicity of the biocide ortho-phenylphenol

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Overview of some aspects of quantitative risk assessment

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Pathological analysis of the carcinogenicity of sodium o-phenylphenate and o-phenylphenol.

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Metabolites of the biocide o-phenylphenol generate oxidative DNA lesions in V 79 cells.

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Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate

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DNA damage induced by metabolites of o-phenylphenol in the presence of copper(II) ion

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Effects of pH on nonenzymatic oxidation of phenylhydroquinone: potential role in urinary bladder carcinogenesis induced by o-phenylphenol in Fischer 344 rats

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Dose-response relationships in chemical carcinogenesis: superposition of different mechanisms of action, resulting in linear-nonlinear curves, practical thresholds, J-shapes

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Correlation between the DNA damage in urinary bladder epithelium and the urinary 2-phenyl-1,4-benzoquinone levels from F344 rats fed sodium o-phenylphenate in the diet

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Risk assessment and regulatory decision making

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The metabolic profile of sodium o-phenylphenate after subchronic oral administration to rats

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The rat as a model for human toxicological evaluation

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7 January 2021

Examination of microsomal cytochrome P450-catalyzed in vitro activation of o-phenylphenol to DNA binding metabolite(s) by 32P-postlabeling technique

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7 January 2021

Biochemical factors involved in the effects of orthophenylphenol (OPP) and sodium orthophenylphenate (SOPP) on the urinary tract of male F344 rats

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7 January 2021

Evaluation of the dose response and in utero exposure to saccharin in the rat

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7 January 2021

Urinary physiologic and chemical metabolic effects on the urothelial cytotoxicity and potential DNA adducts of o-phenylphenol in male rats.

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Dietary effects of ortho-phenylphenol and sodium ortho-phenylphenate on rat urothelium

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7 January 2021

Toxicological profile for o-phenylphenol and its sodium salt

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Sulfhydryl compounds inhibit the cyto- and geno-toxicity of o-phenylphenol metabolites in CHO-K1 cells

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Identifiers

DOI

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1 November 2017

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