Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. (Q42528174)

1 November 2017

Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice (English)

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12 May 2020

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2

Robert J Lefkowitz

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12 May 2020

3

Marc G Caron

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12 May 2020

1

Laura M Bohn

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12 May 2020

language of work or name

English

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publication date

1 December 2002

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1 November 2017

Journal of Neuroscience

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12 May 2020

volume

22

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12 May 2020

issue

23

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12 May 2020

page(s)

10494-10500

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Opioids: first lessons from knockout mice

12 May 2020

cites work

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12 December 2020

The competitive NMDA receptor antagonist LY235959 modulates the progression of morphine tolerance in rats

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12 December 2020

Alteration of spinal protein kinase C expression and kinetics in morphine, but not clonidine, tolerance

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12 December 2020

Involvement of phospholipid signal transduction pathways in morphine tolerance in mice

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12 December 2020

Enhanced morphine analgesia in mice lacking beta-arrestin 2

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12 December 2020

Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade

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12 December 2020

Protein kinase C-mediated acute tolerance to peripheral mu-opioid analgesia in the bradykinin-nociception test in mice

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12 December 2020

Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion

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12 December 2020

Potentiated opioid analgesia in norepinephrine transporter knock-out mice.

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12 December 2020

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

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12 December 2020

Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.

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12 December 2020

Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice

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12 December 2020

mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin

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12 December 2020

The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats

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12 December 2020

Effects of morphine upon the lamina V type cells activities in the dorsal horn of the decerebrate cat

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12 December 2020

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

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12 December 2020

Central nervous system mechanisms of analgesia

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12 December 2020

Anatomy of CNS opioid receptors

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12 December 2020

Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered mu-opioid receptor agonist in the mouse

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12 December 2020

MK-801 inhibits the development of morphine tolerance at spinal sites.

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12 December 2020

kappa-Opioid agonist modulation of [3H]thymidine incorporation into DNA: evidence for the involvement of pertussis toxin-sensitive G protein-coupled phosphoinositide turnover

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12 December 2020

Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats.

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12 December 2020

Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters.

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12 December 2020

Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment

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12 December 2020

Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia

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12 December 2020

Pharmacology and mechanisms of opioid analgesic activity

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12 December 2020

The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy.

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12 December 2020

Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance

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12 December 2020

N-Methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C.

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12 December 2020

Molecular mechanisms of G protein-coupled receptor desensitization and resensitization

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12 December 2020

The role of receptor kinases and arrestins in G protein-coupled receptor regulation

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12 December 2020

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

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12 December 2020

G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

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12 December 2020

Morphine-activated opioid receptors elude desensitization by beta-arrestin

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12 December 2020

Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.

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12 December 2020

10.1523/JNEUROSCI.22-23-10494.2002

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758751&resulttype=core&format=json

12 May 2020

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12 May 2020

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