Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa. (Q42533684)

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17 January 2020

title

Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa (English)

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17 January 2020

3

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17 January 2020

author name string

Fatbardha Varfaj

1

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17 January 2020

Julie Neuberg

2

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17 January 2020

Hironao Wakabayashi

4

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17 January 2020

Philip J Fay

5

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17 January 2020

language of work or name

English

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publication date

1 June 2006

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17 January 2020

number of pages

8

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inferred from page(s)

published in

Biochemical Journal

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17 January 2020

volume

396

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17 January 2020

issue

2

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17 January 2020

page(s)

355-362

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Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P1 site

17 January 2020

cites work

1 reference

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Activation of factor VIII and mechanisms of cofactor action

28 May 2018

1 reference

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The regulation of clotting factors

28 May 2018

1 reference

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Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C

28 May 2018

1 reference

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Mutation in blood coagulation factor V associated with resistance to activated protein C.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Molecular cloning of a cDNA encoding human antihaemophilic factor

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Structure of human factor VIII

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Exosite-dependent regulation of factor VIIIa by activated protein C.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Extended interactions with prothrombinase enforce affinity and specificity for its macromolecular substrate

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Expression of active human factor VIII from recombinant DNA clones

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Structural basis for the decreased procoagulant activity of human factor VIII compared to the porcine homolog.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462720

Altered interactions between the A1 and A2 subunits of factor VIIIa following cleavage of A1 subunit by factor Xa

16 August 2018

1 reference

12 December 2020

Mechanisms of factor Xa-catalyzed cleavage of the factor VIIIa A1 subunit resulting in cofactor inactivation

1 reference

12 December 2020

Phospholipid vesicle formation and transmembrane protein incorporation using octyl glucoside

1 reference

12 December 2020

Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA

1 reference

12 December 2020

Subunit structure of thrombin-activated porcine factor VIII

1 reference

12 December 2020

Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit

1 reference

12 December 2020

Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity

1 reference

12 December 2020

Factor VIII and factor VIIIa

1 reference

12 December 2020

Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive site

1 reference

12 December 2020

Characterization of the molecular defect in factor VR506Q

1 reference

12 December 2020

Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase

1 reference

12 December 2020

Localization of a factor X interactive site in the A1 subunit of factor VIIIa

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20060117

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16503879%20AND%20SRC:MED&resulttype=core&format=json

release_lv3nb37c3fgclednkgtrw3zedy

17 January 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/lv3nb37c3fgclednkgtrw3zedy

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16503879%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

16503879

1 reference