Functional characterization of the adenylyl cyclase gene sgs-1 by analysis of a mutational spectrum in Caenorhabditis elegans. (Q42535008)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12019229%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

title

Functional characterization of the adenylyl cyclase gene sgs-1 by analysis of a mutational spectrum in Caenorhabditis elegans (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12019229%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

main subject

Caenorhabditis elegans

0 references

author name string

Celine Moorman

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12019229%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Ronald H A Plasterk

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12019229%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

language of work or name

English

0 references

publication date

1 May 2002

1 reference

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9 November 2019

number of pages

10

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based on heuristic

inferred from page(s)

published in

Genetics

1 reference

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9 November 2019

volume

161

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9 November 2019

issue

1

1 reference

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9 November 2019

page(s)

133-142

1 reference

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Molecular biological approaches to unravel adenylyl cyclase signaling and function

9 November 2019

cites work

1 reference

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The G-protein beta-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16

28 May 2018

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eat-11 encodes GPB-2, a Gbeta(5) ortholog that interacts with G(o)alpha and G(q)alpha to regulate C. elegans behavior

28 May 2018

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Persistent interactions between the two transmembrane clusters dictate the targeting and functional assembly of adenylyl cyclase

28 May 2018

1 reference

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Characterisation of human adenylyl cyclase IX reveals inhibition by Ca(2+)/Calcineurin and differential mRNA plyadenylation

28 May 2018

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Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites.

28 May 2018

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Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release

28 May 2018

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Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans

28 May 2018

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Two-metal-Ion catalysis in adenylyl cyclase

28 May 2018

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Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity

28 May 2018

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Signals from the reproductive system regulate the lifespan of C. elegans

28 May 2018

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Structure, mechanism, and regulation of mammalian adenylyl cyclase

28 May 2018

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Genome sequence of the nematode C. elegans: a platform for investigating biology

28 May 2018

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The genetics of caloric restriction in Caenorhabditis elegans

28 May 2018

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Identification of a Gialpha binding site on type V adenylyl cyclase

28 May 2018

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G protein hyperactivation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration

28 May 2018

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Mutations uncover a role for two magnesium ions in the catalytic mechanism of adenylyl cyclase

28 May 2018

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G alphas-induced neurodegeneration in Caenorhabditis elegans.

28 May 2018

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Genetic selection of mammalian adenylyl cyclases insensitive to stimulation by Gsalpha

28 May 2018

1 reference

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Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

28 May 2018

1 reference

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Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis

28 May 2018

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An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration

28 May 2018

1 reference

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A genetic selection for Caenorhabditis elegans synaptic transmission mutants

28 May 2018

1 reference

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G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos.

28 May 2018

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Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability.

28 May 2018

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28 May 2018

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28 May 2018

Basic culture methods

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Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein GS.

28 May 2018

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A C. elegans mutant that lives twice as long as wild type

28 May 2018

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Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function

28 May 2018

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Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin

28 May 2018

1 reference

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Truncation and alanine-scanning mutants of type I adenylyl cyclase.

28 May 2018

1 reference

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Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis

28 May 2018

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Extrachromosomal DNA transformation of Caenorhabditis elegans

28 May 2018

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GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

28 May 2018

1 reference

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Two G protein oncogenes in human endocrine tumors

28 May 2018

1 reference

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Regulation of mammalian adenylyl cyclases by G-protein alpha and beta gamma subunits

28 May 2018

1 reference

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Two RGS proteins that inhibit Galpha(o) and Galpha(q) signaling in C. elegans neurons require a Gbeta(5)-like subunit for function

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462092

Participation of the protein Go in multiple aspects of behavior in C. elegans

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462092

Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462092

The conserved asparagine and arginine are essential for catalysis of mammalian adenylyl cyclase

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12019229

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The catalytic mechanism of mammalian adenylyl cyclase. Equilibrium binding and kinetic analysis of P-site inhibition

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12019229

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12019229%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

12019229

1 reference