2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors (Q42536068)

1 November 2017

title

2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors (English)

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1 November 2017

P Imbach

1

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1 November 2017

H G Capraro

2

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1 November 2017

P Furet

3

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1 November 2017

H Mett

4

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1 November 2017

T Meyer

5

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1 November 2017

J Zimmermann

6

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1 November 2017

language of work or name

English

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publication date

1 January 1999

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Bioorganic & Medicinal Chemistry Letters

1 November 2017

published in

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1 November 2017

volume

9

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1 November 2017

issue

1

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1 November 2017

page(s)

91-96

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Animal cell cycles and their control

1 November 2017

cites work

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Activation of human cyclin-dependent kinases in vitro

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Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.

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Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases

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Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

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Inhibition of cyclin-dependent kinases by purine analogues

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Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

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Crystal structure of cyclin-dependent kinase 2

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Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

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Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

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Facile Preparation of 2,6-Disubstituted Purines Using Solid-Phase Chemistry

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Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases

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Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds

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cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF

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Interaction between the cell-cycle-control proteins p34cdc2 and p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2

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Identifiers

DOI

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1 November 2017

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