Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis. (Q42537142)

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8 December 2019

title

Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis (English)

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8 December 2019

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3

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8 December 2019

Chris McGuigan

1

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8 December 2019

author name string

Cahard D

2

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8 December 2019

Siddiqui A

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8 December 2019

De Clercq E

5

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8 December 2019

Balzarini J

6

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8 December 2019

language of work or name

English

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publication date

1 November 1998

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Bioorganic & Medicinal Chemistry Letters

8 December 2019

published in

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8 December 2019

volume

8

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8 December 2019

issue

21

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8 December 2019

page(s)

2949-2954

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Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells

8 December 2019

cites work

1 reference

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Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process

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Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.

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7 January 2021

Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

1 reference

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7 January 2021

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

1 reference

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7 January 2021

Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900530-7

7 January 2021

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

1 reference

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7 January 2021

Anti-HIV pronucleotides: decomposition pathways and correlation with biological activities

1 reference

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7 January 2021

10.1016/S0960-894X(98)00530-7

Identifiers

DOI

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release_gje47x3zdzehtknwax447h6rc4

8 December 2019

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/gje47x3zdzehtknwax447h6rc4

24 November 2022

mapped directly with Wikidata item

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