Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR. (Q42547583)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18510319%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR (English)

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8 January 2020

1 reference

1

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8 January 2020

Andrew J Doig

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18510319%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

David A Middleton

series ordinal

3

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8 January 2020

author name string

David A Middleton

series ordinal

3

1 reference

2 November 2017

language of work or name

English

0 references

publication date

30 May 2008

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18510319%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

number of pages

9

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Journal of the American Chemical Society

inferred from page(s)

published in

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8 January 2020

volume

130

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8 January 2020

issue

25

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8 January 2020

page(s)

7873-7881

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18510319%20AND%20SRC:MED&resulttype=core&format=json

Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange

8 January 2020

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3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR.

28 May 2018

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Peptide-based inhibitors of amyloid assembly

28 May 2018

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N-Methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure

28 May 2018

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Small molecule inhibitors of alpha-synuclein filament assembly

28 May 2018

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Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR.

28 May 2018

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Molecular recycling within amyloid fibrils

28 May 2018

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Inhibition of amyloid fibril formation by peptide analogues modified with alpha-aminoisobutyric acid

28 May 2018

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A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders

28 May 2018

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28 May 2018

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Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease.

28 May 2018

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Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril

28 May 2018

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A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

28 May 2018

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Peptide aggregation in neurodegenerative disease

28 May 2018

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Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abeta1-40 fibrillogenesis

28 May 2018

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Probability-based protein secondary structure identification using combined NMR chemical-shift data

28 May 2018

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beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

28 May 2018

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Solubilization and disaggregation of polyglutamine peptides

28 May 2018

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

28 May 2018

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Solid-state NMR as a probe of amyloid fibril structure

28 May 2018

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

28 May 2018

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

28 May 2018

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Alpha-synuclein in Lewy bodies

28 May 2018

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

28 May 2018

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Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

28 May 2018

1 reference

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Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro

28 May 2018

1 reference

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Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue.

16 August 2018

1 reference

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Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis

16 August 2018

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pH-Dependent Amyloid and Protofibril Formation by the ABri Peptide of Familial British Dementia

16 August 2018

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A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein

16 August 2018

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Mapping the core of the beta(2)-microglobulin amyloid fibril by H/D exchange

16 August 2018

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Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

16 August 2018

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Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity

16 August 2018

1 reference

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Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues

16 August 2018

1 reference

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Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation.

16 August 2018

1 reference

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Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

16 August 2018

1 reference

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Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening

16 August 2018

1 reference

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Studies of the aggregation of an amyloidogenic α-synuclein peptide fragment

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2538558

Probing Membrane Surfaces and the Location of Membrane-Embedded Peptides by 13C MAS NMR Using Lanthanide Ions

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2538558

Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease

1 December 2018

1 reference

12 December 2020

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

1 reference

12 December 2020

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

12 December 2020

A modified ninhydrin colorimetric analysis for amino acids

1 reference

12 December 2020

Solid-state NMR in drug design and discovery for membrane-embedded targets

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA075356Q

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18510319%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18510319%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference