Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase (Q42553482)

2 November 2017

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase (English)

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2 November 2017

1

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31 May 2020

Pascal Bonnet

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31 May 2020

author name string

Christophe Adelinet

2

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31 May 2020

Valerio Berdini

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31 May 2020

Lijs Beke

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31 May 2020

Dirk Brehmer

6

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31 May 2020

Frederick Calo

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31 May 2020

Joseph E Coyle

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31 May 2020

Phillip J Day

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31 May 2020

Martyn Frederickson

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31 May 2020

Eddy J E Freyne

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31 May 2020

Ron A H J Gilissen

12

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31 May 2020

Christopher C F Hamlett

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31 May 2020

Steven Howard

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31 May 2020

Lieven Meerpoel

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31 May 2020

Laurence Mevellec

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31 May 2020

Rachel McMenamin

17

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31 May 2020

Elisabeth Pasquier

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31 May 2020

Sahil Patel

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31 May 2020

David C Rees

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31 May 2020

Joannes T M Linders

21

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31 May 2020

publication date

23 May 2014

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ACS Medicinal Chemistry Letters

2 November 2017

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31 May 2020

volume

6

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31 May 2020

issue

1

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31 May 2020

page(s)

31-36

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Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase

31 May 2020

cites work

1 reference

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The 'rule of three' for fragment-based drug discovery: where are we now?

28 May 2018

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Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer

28 May 2018

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Type II kinase inhibitors: an opportunity in cancer for rational design

28 May 2018

1 reference

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The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer

28 May 2018

1 reference

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Experiences in fragment-based drug discovery

28 May 2018

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Total synthesis of (±)-cortistatin J from furan

28 May 2018

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Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers

28 May 2018

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AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

28 May 2018

1 reference

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Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer

28 May 2018

1 reference

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Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase

28 May 2018

1 reference

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Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression

28 May 2018

1 reference

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Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291807

Ba/F3 cells and their use in kinase drug discovery

28 May 2018

1 reference

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Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers

28 May 2018

1 reference

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Ligand efficiency: a useful metric for lead selection

28 May 2018

1 reference

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The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

28 May 2018

1 reference

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Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells

28 May 2018

1 reference

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16 August 2018

Identifiers

DOI

10.1021/ML5001273

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31 May 2020

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31 May 2020

PubMed publication ID

25589926

1 reference