Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice. (Q42599817)

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4 March 2020

title

Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice (English)

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7

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Thomas P Roddy

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Stephen F Previs

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author name string

Seongah Han

1

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Taro E Akiyama

2

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Kithsiri Herath

4

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Kristian K Jensen

6

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Beth A Murphy

8

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Lesley A McNamara

9

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Xun Shen

10

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Walter Strapps

11

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Brian K Hubbard

12

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Shirly Pinto

13

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Cai Li

14

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Jing Li

15

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publication date

4 July 2013

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Journal of Lipid Research

4 March 2020

published in

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volume

54

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issue

10

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page(s)

2615-2622

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The role of dysregulated glucagon secretion in type 2 diabetes

4 March 2020

cites work

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Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.

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siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids

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28 May 2018

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The glucagon receptor is required for the adaptive metabolic response to fasting

28 May 2018

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Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet

28 May 2018

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p38 mitogen-activated protein kinase plays an inhibitory role in hepatic lipogenesis

28 May 2018

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Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

28 May 2018

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Lipids and lipoproteins in patients with type 2 diabetes

28 May 2018

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Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

28 May 2018

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Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification

28 May 2018

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Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters.

16 August 2018

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Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia

16 August 2018

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Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice.

16 August 2018

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A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects

16 August 2018

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Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice

16 August 2018

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Glycemic control in mice with targeted disruption of the glucagon receptor gene

16 August 2018

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Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans

16 August 2018

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Hypolipemic action of glucagon in experimental endogenous lipemia in the rat.

16 August 2018

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In vivo measurement of fatty acids and cholesterol synthesis using D2O and mass isotopomer analysis

16 August 2018

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Insulin Resistance and Atherosclerosis

16 August 2018

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Crossref

https://api.crossref.org/works/10.1194%2FJLR.M035592

Effects of glucagon on plasma lipids in different types of primary hyperlipoproteinemia

21 January 2018

1 reference

12 December 2020

In vivo measurement of plasma cholesterol and fatty acid synthesis with deuterated water: determination of the average number of deuterium atoms incorporated

1 reference

12 December 2020

Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

1 reference

12 December 2020

Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice

1 reference

12 December 2020

Comparison of lipoprotein separation and lipid analysis methodologies for human and cynomolgus monkey plasma samples

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12 December 2020

Identifiers

DOI

10.1194/JLR.M035592

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23828778%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

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4 March 2020

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