Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos (Q42600518)

3 November 2017

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos (English)

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3 November 2017

9

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3 November 2017

Julie Bianchi

7

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author name string

Pierre Hentges

1

1 reference

3 November 2017

Peter Ahnesorg

2

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3 November 2017

Robert S Pitcher

3

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3 November 2017

Chris K Bruce

4

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3 November 2017

Boris Kysela

5

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3 November 2017

Andrew J Green

6

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3 November 2017

Thomas E Wilson

8

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3 November 2017

Aidan J Doherty

10

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3 November 2017

language of work or name

English

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publication date

12 October 2006

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Journal of Biological Chemistry

3 November 2017

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3 November 2017

281

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3 November 2017

37517-37526

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3 November 2017

49

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Chromosomal stability and the DNA double-stranded break connection

3 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Mechanism of DNA double-strand break repair by non-homologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

The role of DNA dependent protein kinase in synapsis of DNA ends.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Synapsis of DNA ends by DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Crystal structure of an Xrcc4-DNA ligase IV complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

A biochemically defined system for mammalian nonhomologous DNA end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

DNA joint dependence of pol X family polymerase action in nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Nonhomologous end joining and V(D)J recombination require an additional factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Three novel antibiotic marker cassettes for gene disruption and marker switching in Schizosaccharomyces pombe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

A DNA microarray-based genetic screen for nonhomologous end-joining mutants in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

MUSCLE: multiple sequence alignment with high accuracy and high throughput

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Hemiascomycetous yeasts at the forefront of comparative genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Highly variable rates of genome rearrangements between hemiascomycetous yeast lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608727200

21 January 2018

Identifiers

DOI

10.1074/JBC.M608727200

1 reference

3 November 2017

1 reference