Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans (Q42615072)

3 November 2017

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans (English)

1 reference

Has domain(s) with predicted electron carrier activity, heme binding, iron ion binding, monooxygenase activity, oxidoreductase activity and acting on paired donors, more

3 November 2017

1 reference

GeneDB

5 February 2019

putative cytochrome P450

1 reference

GeneDB

Protease inhibitor, putative

6 February 2019

0 references

Putative monooxygenase

0 references

Putative alcohol dehydrogenase

0 references

protein of unknown function

0 references

Putative cytochrome P450 monooxygenase

0 references

Putative enoyl reductase

0 references

Putative FAD-dependent monooxygenase

0 references

Putative cytochrome P450 monooxygenase

0 references

Putative hybrid polyketide synthase-nonribosomal peptide synthase (PKS-NRPS)

0 references

Putative exporter

0 references

Putative Zn(II)2Cys6 transcription factor

0 references

Putative acyl-CoA dehydrogenase

0 references

Plasma membrane uracil transmembrane transporter, putative

0 references

1 reference

1 reference

1 reference

6

1 reference

3 November 2017

3

Kirstin Scherlach

1 reference

3 November 2017

5

Axel A Brakhage

1 reference

3 November 2017

Sebastian Bergmann

1

1 reference

PubMed ID

17369821

3 November 2017

Julia Schümann

series ordinal

2

1 reference

PubMed ID

17369821

3 November 2017

Corinna Lange

series ordinal

4

1 reference

3 November 2017

18 March 2007

1 reference

3 November 2017

Nature Chemical Biology

1 reference

3 November 2017

3

1 reference

3 November 2017

213-217

1 reference

3 November 2017

4

1 reference

https://scigraph.springernature.com/pub.10.1038/nchembio869

3 November 2017

0 references

cites work

Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

Microbial genomics for the improvement of natural product discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Genomic approaches to drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Mining the microbial metabolome: a new frontier for natural product lead discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

The impact of bacterial genomics on natural product research.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Genomic mining for Aspergillus natural products

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Structure of trichamide, a cyclic peptide from the bloom-forming cyanobacterium Trichodesmium erythraeum, predicted from the genome sequence.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Genome mining to identify new plant triterpenoids

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Genome-inspired search for new antibiotics. Isolation and structure determination of new 28-membered polyketide macrolactones, halstoctacosanolides A and B, from Streptomyces halstedii HC34

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Equisetin biosynthesis in Fusarium heterosporum

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

The genome sequence of the rice blast fungus Magnaporthe grisea

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

A putative polyketide synthase/peptide synthetase from Magnaporthe grisea signals pathogen attack to resistant rice.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Functional analysis of the polyketide synthase genes in the filamentous fungus Gibberella zeae (anamorph Fusarium graminearum).

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Characterization of an inducible expression system in Aspergillus nidulans using alcA and tubulin-coding genes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Assignment of Relative Configuration to Acyclic Compounds Based on (13)C NMR Shifts. A Density Functional and Molecular Mechanics Study

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Novel tetramic acids and pyridone alkaloids, militarinones B, C, and D, from the insect pathogenic fungus Paecilomyces militaris

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Tenellin and bassianin, metabolites of Beauveria species. Structure elucidation with 15N- and doubly 13C-enriched compounds using 13C nuclear magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Farinosones A-C, neurotrophic alkaloidal metabolites from the entomogenous deuteromycete Paecilomyces farinosus

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Synthesis and evaluation of a putative acyl tetramic acid intermediate in tenellin biosynthesis in Beauveria bassiana. A new role for tyrosine

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Paecilosetin, a new bioactive fungal metabolite from a New Zealand isolate of Paecilomyces farinosus.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO869

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO869

1 reference

3 November 2017

1 reference

PubMed ID

17369821