Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. (Q42646107)

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English	Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.	scientific article

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scholarly article

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12 November 2019

Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding (English)

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12 November 2019

Toxoplasma gondii

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crystal structure

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based on heuristic

inferred from title

2

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12 November 2019

4

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12 November 2019

author name string

M A Schumacher

1

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12 November 2019

D M Scott

3

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12 November 2019

B Ullman

5

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12 November 2019

R G Brennan

6

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12 November 2019

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1 June 1998

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12 November 2019

The EMBO Journal

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12 November 2019

17

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12 November 2019

12

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12 November 2019

3219-3232

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12 November 2019

Two non-proline cis peptide bonds may be important for factor XIII function

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Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli

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The transactivation region of the fis protein that controls site-specific DNA inversion contains extended mobile beta-hairpin arms

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Crystal structure of Escherichia coli xanthine phosphoribosyltransferase

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A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase

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Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop

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Enzymes of nucleotide synthesis

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Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus

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A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase

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Mutagenesis supports water mediated recognition in the trp repressor-operator system.

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Structure of the allosteric regulatory enzyme of purine biosynthesis

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27 May 2018

Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii

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27 May 2018

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

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Insertional mutagenesis and marker rescue in a protozoan parasite: cloning of the uracil phosphoribosyltransferase locus from Toxoplasma gondii

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Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase: protein complementation reveals shared active sites

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The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate

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Structural features of the phosphoribosyltransferases and their relationship to the human deficiency disorders of purine and pyrimidine metabolism

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Uracil phosphoribosyltransferase from Acholeplasma laidlawii: partial purification and kinetic properties

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Solvent content of protein crystals

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Purification and some properties of uracil phosphoribosyltransferase from Escherichia coli K12.

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Primary 14C and alpha secondary 3H substrate kinetic isotope effects for some phosphoribosyltransferases

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Expression, purification, and characterization of uracil phosphoribosyltransferase from Toxoplasma gondii.

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The conserved serine-tyrosine dipeptide in Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase is essential for catalytic activity.

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Pyrimidine Synthesis by Intracellular Toxoplasma gondii

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Purification and characterization of uracil phosphoribosyltransferase from Crithidia luciliae

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Identifiers

10.1093/EMBOJ/17.12.3219

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12 November 2019

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12 November 2019

1 reference

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12 November 2019

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