Identification of a novel transcriptional repressor element located in the first intron of the human BRCA1 gene (Q42647919)

4 November 2017

title

Identification of a novel transcriptional repressor element located in the first intron of the human BRCA1 gene (English)

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4 November 2017

Suen TC

1

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4 November 2017

Goss PE

series ordinal

2

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4 November 2017

language of work or name

English

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publication date

1 January 2001

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4 November 2017

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4 November 2017

volume

20

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4 November 2017

issue

4

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4 November 2017

page(s)

440-450

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204078

4 November 2017

exact match

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cites work

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Functions of the BRCA1 and BRCA2 genes

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Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice.

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The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells

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High-efficiency transformation of mammalian cells by plasmid DNA

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Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation

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Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium

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BRCA1 mutations in primary breast and ovarian carcinomas

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Growth retardation and tumour inhibition by BRCA1.

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A somatic BRCA1 mutation in an ovarian tumour

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Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice

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Construction of plasmids that express E. coli beta-galactosidase in mammalian cells.

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CpG methylation within the 5' regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site

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Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region

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The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

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Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

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Evidence for a transcriptional activation function of BRCA1 C-terminal region

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Brca1 controls homology-directed DNA repair

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BRCA1 regulates p53-dependent gene expression

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CBP/p300 interact with and function as transcriptional coactivators of BRCA1

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A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

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Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells

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BRCA1 is a cell cycle-regulated nuclear phosphoprotein

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BRCA1 is a component of the RNA polymerase II holoenzyme

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Genetic analysis of BRCA1 function in a defined tumor cell line

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The ETS-domain transcription factor family

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A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

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Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

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Multiple cis- and trans-acting elements involved in regulation of the neu gene

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Characterization of a repressor element and a juxtaposed tissue-restricted activator element located on the distal neu gene promoter

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Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

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Distinct transcription start sites generate two forms of BRCA1 mRNA.

21 January 2018

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Complex regulation of the BRCA1 gene.

21 January 2018

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Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene

21 January 2018

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

21 January 2018

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BRCA1 interacts with components of the histone deacetylase complex

21 January 2018

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BRCA1 physically associates with p53 and stimulates its transcriptional activity.

21 January 2018

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Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome

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Transcriptional activation by BRCA1

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The BRCA1 and BRCA2 breast cancer genes.

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7 January 2021

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

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7 January 2021

High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. The Breast Cancer Linkage Consortium

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204078

7 January 2021

Activation of transcription in vitro by the BRCA1 carboxyl-terminal domain

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204078

7 January 2021

Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer

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7 January 2021

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204078

7 January 2021

BRCA1 expression during prenatal development of the human mammary gland

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204078

7 January 2021

Decreased BRCA1 expression levels may arrest the cell cycle through activation of p53 checkpoint in human sporadic breast tumors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204078

7 January 2021

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

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7 January 2021

A sporadic breast tumor with a somatically acquired complex genomic rearrangement in BRCA1

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204078

1 reference

Dimensions Publication ID

4 November 2017

1043966837

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1 reference