The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol (Q42655247)

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English	The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol	scientific article

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scholarly article

1 reference

Europe PubMed Central

4 November 2017

The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol (English)

1 reference

Europe PubMed Central

4 November 2017

Trypanosoma brucei

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CDP-diacylglycerol--inositol 3-phosphatidyltransferase, putative

1 reference

5 February 2019

CDP-diacylglycerol--inositol 3-phosphatidyltransferase, putative

1 reference

6 February 2019

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

0 references

CDP-diacylglycerol--inositol 3-phosphatidyltransferase, putative

0 references

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

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CDP-diacylglycerol--inositol 3-phosphatidyltransferase

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author name string

Kirstee L Martin

1

1 reference

Europe PubMed Central

4 November 2017

Terry K Smith

2

1 reference

Europe PubMed Central

4 November 2017

language of work or name

0 references

publication date

1 July 2006

1 reference

Europe PubMed Central

4 November 2017

Molecular Microbiology

1 reference

Europe PubMed Central

4 November 2017

61

1 reference

Europe PubMed Central

4 November 2017

1

1 reference

Europe PubMed Central

4 November 2017

89-105

1 reference

Europe PubMed Central

4 November 2017

Phosphatidylinositol synthesis is essential in bloodstream form Trypanosoma brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Diversification and evolution of L‐myo‐inositol 1‐phosphate synthase1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Inhibitors of glycosyl-phosphatidylinositol anchor biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis

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27 May 2018

Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei

1 reference

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27 May 2018

Generation of myo-inositol-auxotrophic Leishmania mexicana mutants by targeted replacement of the myo-inositol-1-phosphate synthase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Acyl-CoA binding protein is essential in bloodstream form Trypanosoma brucei

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27 May 2018

Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis

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27 May 2018

Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Recent developments in the cell biology and biochemistry of glycosylphosphatidylinositol lipids (review).

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness.

1 reference

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27 May 2018

The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research.

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27 May 2018

A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

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27 May 2018

L-myo-Inositol 1-phosphate synthase from Entamoeba histolytica.

1 reference

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27 May 2018

Mammalian glycophosphatidylinositol anchor transfer to proteins and posttransfer deacylation

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27 May 2018

Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

1L-myo-inositol-1-phosphate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Antigenic variation in trypanosomes: secrets surface slowly

1 reference

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27 May 2018

Substrate specificity of the dolichol phosphate mannose: glucosaminyl phosphatidylinositol alpha1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Myristate exchange on the Trypanosoma brucei variant surface glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

The role of inositol acylation and inositol deacylation in GPI biosynthesis in Trypanosoma brucei.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

myo-Inositol-1-phosphate synthase. Characteristics of the enzyme and identification of its structural gene in yeast

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Biosynthesis of glycosyl-phosphatidylinositol lipids in Trypanosoma brucei: involvement of mannosyl-phosphoryldolichol as the mannose donor

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Growth and metabolism of inositol-starved Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

27 May 2018

Deletion of the glucosidase II gene in Trypanosoma brucei reveals novel N-glycosylation mechanisms in the biosynthesis of variant surface glycoprotein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

16 August 2018

Function of phosphatidylinositol in mycobacteria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

16 August 2018

Characterization of recombinant Drosophila melanogaster myo-inositol-1-phosphate synthase expressed in Escherichia coli.

1 reference

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16 August 2018

Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast

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16 August 2018

A novel salt-tolerant L-myo-inositol-1-phosphate synthase from Porteresia coarctata (Roxb.) Tateoka, a halophytic wild rice: molecular cloning, bacterial overexpression, characterization, and functional introgression into tobacco-conferring salt tol

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16 August 2018

cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase

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16 August 2018

Properties of phosphoenolpyruvate mutase, the first enzyme in the aminoethylphosphonate biosynthetic pathway in Trypanosoma cruzi

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16 August 2018

Intracellular trafficking of glycosylphosphatidylinositol (GPI)-anchored proteins and free GPIs in Leishmania mexicana

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

16 August 2018

YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanolaminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

16 August 2018

Biosynthesis of glycosylphosphatidylinositols of Plasmodium falciparum in a cell-free incubation system: inositol acylation is needed for mannosylation of glycosylphosphatidylinositols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

16 August 2018

The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793301

16 August 2018

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

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21 January 2018

1 L-myo-Inositol 1-Phosphate Synthase from Arabidopsis thaliana

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of biosynthesis of myo-inositol from glucose 6-phosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-free synthesis of glycosyl-phosphatidylinositol precursors for the glycolipid membrane anchor of Trypanosoma brucei variant surface glycoproteins. Structural characterization of putative biosynthetic intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delineation of three pathways of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana. Precursors from different pathways are assembled on distinct pools of phosphatidylinositol and undergo fatty acid remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of abnormal free glycophosphatidylinositols accumulating in mutant lymphoma cells of classes B, E, F, and H

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Candidate glycophospholipid precursor for the glycosylphosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel pathway for glycan assembly: biosynthesis of the glycosyl-phosphatidylinositol anchor of the trypanosome variant surface glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid remodeling: A novel reaction sequence in the biosynthesis of trypanosome glycosyl phosphatidylinositol membrane anchors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new micromethod for the colorimetric determination of inorganic phosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycosyl Phosphatidylinositol Myristoylation in African Trypanosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucosylation of Glycosylphosphatidylinositol Membrane Anchors: Identification of Uridine Diphosphate−Glucose as the Direct Donor for Side Chain Modification inToxoplasma gondiiUsing Carbohydrate Analogues†

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of complete precursors for the glycosylphosphatidylinositol protein anchors of Trypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/16824097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2958.2006.05216.X

1 reference

Europe PubMed Central

4 November 2017

1 reference

Europe PubMed Central

4 November 2017

1 reference

Europe PubMed Central

4 November 2017

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