The role of germline promoters and I exons in cytokine-induced gene-specific class switch recombination. (Q42699528)

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17 January 2020

title

The role of germline promoters and I exons in cytokine-induced gene-specific class switch recombination (English)

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17 January 2020

3

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17 January 2020

author name string

Wesley A Dunnick

1

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17 January 2020

Jian Shi

2

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17 January 2020

Clinton Fontaine

4

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17 January 2020

John T Collins

5

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17 January 2020

language of work or name

English

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publication date

3 December 2010

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17 January 2020

published in

Journal of Immunology

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17 January 2020

volume

186

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17 January 2020

issue

1

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17 January 2020

page(s)

350-358

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Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes.

17 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Switch region identity plays an important role in Ig class switch recombination

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Molecular processes that regulate class switching

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Processing of switch transcripts is required for targeting of antibody class switch recombination

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Shutdown of class switch recombination by deletion of a switch region control element.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Germline transcripts of the murine immunoglobulin gamma 2a gene: structure and induction by IFN-gamma

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokine(s)

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Regulation of Ig Class Secretion by Soluble Products of Certain T-Cell Lines

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Structure of Germline Immunoglobulin Heavy-Chainγ1 Transcripts in Interleukin 4 Treated Mouse Spleen Cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Increased targeting of donor switch region and IgE in Sgamma1-deficient B cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059604

Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production

16 August 2018

1 reference

12 December 2020

Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination

1 reference

12 December 2020

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1 reference

12 December 2020

Switch transcripts in immunoglobulin class switching

1 reference

12 December 2020

Induction of germ-line gamma 1 and epsilon Ig gene expression in murine B cells. IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals

1 reference

12 December 2020

Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice

1 reference

12 December 2020

Integrating signals from IFN-gamma and IL-4 by B cells: positive and negative effects on CD40 ligand-induced proliferation, survival, and division-linked isotype switching to IgG1, IgE, and IgG2a

1 reference

12 December 2020

Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1003108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21131417%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

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17 January 2020

PubMed publication ID

21131417

1 reference