Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. (Q42715697)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23009203%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth (English)

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9 March 2020

4

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9 March 2020

author name string

Joel A Bergman

1

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9 March 2020

Karrune Woan

2

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9 March 2020

Patricio Perez-Villarroel

3

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9 March 2020

Eduardo M Sotomayor

5

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9 March 2020

Alan P Kozikowski

6

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9 March 2020

language of work or name

English

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publication date

23 October 2012

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Journal of Medicinal Chemistry

9 March 2020

published in

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9 March 2020

volume

55

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9 March 2020

issue

22

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9 March 2020

page(s)

9891-9899

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Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.

9 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

27 May 2018

1 reference

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Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10.

27 May 2018

1 reference

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Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Characterization of the two catalytic domains in histone deacetylase 6.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562128

Efficient iron-catalyzed N-arylation of aryl halides with amines

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23009203

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis of secondary arylamines through copper-mediated intermolecular aryl amination

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23009203

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Copper-catalyzed coupling of alkylamines and aryl iodides: an efficient system even in an air atmosphere

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23009203

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM301098E

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23009203%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23009203%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference