Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation. (Q42742643)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784730%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation (English)

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9 January 2020

2

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9 January 2020

Brian Huntly

5

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9 January 2020

author name string

Jing Chen

1

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9 January 2020

Benjamin H Lee

3

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9 January 2020

Nicole Duclos

4

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9 January 2020

Daniel J Donoghue

6

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9 January 2020

D Gary Gilliland

7

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9 January 2020

language of work or name

English

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publication date

22 March 2005

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9 January 2020

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9 January 2020

volume

106

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9 January 2020

issue

1

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9 January 2020

page(s)

328-337

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Transforming property of TEL-FGFR3 mediated through PI3-K in a T-cell lymphoma that subsequently progressed to AML.

9 January 2020

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The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling

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Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.

27 May 2018

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The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

27 May 2018

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Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events

27 May 2018

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FGF receptors ubiquitylation: dependence on tyrosine kinase activity and role in downregulation

27 May 2018

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Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation

27 May 2018

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Chromosome translocations in multiple myeloma

27 May 2018

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Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

27 May 2018

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The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells

27 May 2018

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Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

27 May 2018

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Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

27 May 2018

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Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

27 May 2018

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The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

27 May 2018

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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

27 May 2018

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Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma

27 May 2018

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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

27 May 2018

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Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

27 May 2018

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Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein

27 May 2018

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Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma

27 May 2018

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Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines.

27 May 2018

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Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

27 May 2018

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Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

27 May 2018

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Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

27 May 2018

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27 May 2018

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Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia

27 May 2018

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27 May 2018

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A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

27 May 2018

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Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

27 May 2018

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Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells

27 May 2018

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27 May 2018

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The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant

16 August 2018

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16 August 2018

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Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

16 August 2018

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Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

16 August 2018

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Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

16 August 2018

1 reference

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Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis

3 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15784730

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2004-09-3686

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784730%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784730%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference