The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin (Q42754872)

6 November 2017

The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin (English)

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6 November 2017

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Kyung-Soo Chun

1

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PubMed ID

21268125

6 November 2017

Robert Langenbach

series ordinal

2

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6 November 2017

25 January 2011

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6 November 2017

Molecular Carcinogenesis

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6 November 2017

50

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6 November 2017

6

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6 November 2017

439-448

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Skin cancer and solar UV radiation

6 November 2017

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UV-induced cutaneous photobiology

21 January 2018

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COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

21 January 2018

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Cyclooxygenases: structural, cellular, and molecular biology

21 January 2018

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Prostaglandin synthase 2.

21 January 2018

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Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4.

21 January 2018

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A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesis

21 January 2018

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Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure.

21 January 2018

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EP2 and EP4 prostanoid receptor signaling

21 January 2018

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Prostanoid receptors: subtypes and signaling

21 January 2018

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Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer?

21 January 2018

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Prostaglandin E2 protects gastric mucosal cells from apoptosis via EP2 and EP4 receptor activation

21 January 2018

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Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine

21 January 2018

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Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting

21 January 2018

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UVB-induced apoptosis drives clonal expansion during skin tumor development

21 January 2018

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PGE2 confers survivin-dependent apoptosis resistance in human monocyte-derived dendritic cells

21 January 2018

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Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients.

21 January 2018

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Cigarette smoke and increased COX-2 and survivin levels in exhaled breath condensate of lung cancer patients: how hot is the link?

21 January 2018

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Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence

21 January 2018

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Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.

21 January 2018

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Celecoxib reduces the effects of acute and chronic UVB exposure in mice treated with therapeutically relevant immunosuppressive drugs

21 January 2018

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The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development

21 January 2018

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STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.

21 January 2018

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Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

21 January 2018

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Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion

21 January 2018

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EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways

21 January 2018

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Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression

21 January 2018

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Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells

21 January 2018

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Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis

21 January 2018

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Epidermal growth factor receptor (EGFR) signaling in cancer

21 January 2018

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A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skin

21 January 2018

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Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells

21 January 2018

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Celecoxib and NS-398 enhance photodynamic therapy by increasing in vitro apoptosis and decreasing in vivo inflammatory and angiogenic factors

21 January 2018

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Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells

21 January 2018

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Cyclooxygenase-2 overexpression in MCF-10F human breast epithelial cells inhibits proliferation, apoptosis and differentiation, and causes partial transformation

21 January 2018

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Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice

21 January 2018

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The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia

21 January 2018

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Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development.

21 January 2018

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Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms.

21 January 2018

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Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo

21 January 2018

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Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells

21 January 2018

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Prostaglandin E2 upregulates survivin expression via the EP1 receptor in hepatocellular carcinoma cells

21 January 2018

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Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells

21 January 2018

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Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparities

21 January 2018

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Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2.

21 January 2018

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The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

21 January 2018

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Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells

21 January 2018

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Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer

21 January 2018

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Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

21 January 2018

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A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.

21 January 2018

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Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors

21 January 2018

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Linkage between EGFR family receptors and nuclear factor kappaB (NF-kappaB) signaling in breast cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MC.20728

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6 November 2017

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PubMed ID

21268125