Synthesis of 5-fluoroalkylated pyrimidine nucleosides via Negishi cross-coupling (Q42770845)

7 November 2017

Synthesis of 5-fluoroalkylated pyrimidine nucleosides via Negishi cross-coupling (English)

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7 November 2017

1

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7 November 2017

Wenchao Qu

2

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7 November 2017

Hank F Kung

series ordinal

3

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7 November 2017

language of work or name

English

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publication date

4 June 2008

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Journal of Organic Chemistry

7 November 2017

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7 November 2017

73

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7 November 2017

13

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7 November 2017

4874-4881

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Recent developments to improve the efficacy of cytotoxic nucleoside analogues.

7 November 2017

1 reference

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Insights into the mechanism of the Negishi reaction: ZnRX versus ZnR2 reagents

27 May 2018

1 reference

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Alkyl-fluorinated thymidine derivatives for imaging cell proliferation II. Synthesis and evaluation of N3-(2-[18F]fluoroethyl)-thymidine

27 May 2018

1 reference

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Efficient Synthesis of Functionalized Organozinc Compounds by the Direct Insertion of Zinc into Organic Iodides and Bromides

27 May 2018

1 reference

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Imaging herpes viral thymidine kinase-1 reporter gene expression with a new 18F-labeled probe: 2'-fluoro-2'-deoxy-5-[18F]fluoroethyl-1-beta-d-arabinofuranosyl uracil

27 May 2018

1 reference

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Reporter gene imaging: potential impact on therapy.

27 May 2018

1 reference

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The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst

27 May 2018

1 reference

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5-(1-Substituted) alkyl pyrimidine nucleosides as antiviral (herpes) agents

27 May 2018

1 reference

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Positron emission tomography and gene therapy: basic concepts and experimental approaches for in vivo gene expression imaging.

27 May 2018

1 reference

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Synthesis and biological activities of iododeoxyuridine, an analog of thymidine

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Highly efficient, general procedure for the preparation of alkylzinc reagents from unactivated alkyl bromides and chlorides

27 May 2018

1 reference

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PET imaging of gene expression

27 May 2018

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Nucleoside analogues and nucleobases in cancer treatment.

27 May 2018

1 reference

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Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication

27 May 2018

1 reference

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L-Nucleosides as chemotherapeutic agents

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An improved synthesis of functionalized biphenyl-based phosphine ligands.

27 May 2018

1 reference

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27 May 2018

1 reference

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Mechanism-based inactivation of thymidylate synthase by 5-(3-fluoropropyn-1-yl)-2'-deoxyuridine 5'-phosphate

27 May 2018

1 reference

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Suicide gene therapy of chemically induced mammary tumor in rat: efficacy and distant bystander effect.

27 May 2018

1 reference

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Synthesis and biological properties of 5-o-carboranyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil

27 May 2018

1 reference

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Metabolic suicide genes in gene therapy

27 May 2018

1 reference

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An investigation by 1H NMR spectroscopy into the factors determining the beta:alpha ratio of the product in 2'-deoxynucleoside synthesis

27 May 2018

1 reference

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Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogs: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyridine against herpes simplex virus type 1

27 May 2018

1 reference

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Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with Herpesvirus genetic information

27 May 2018

1 reference

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2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity

27 May 2018

1 reference

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A practical synthesis of 2-deoxy-2-fluoro-d-arabinofuranose derivatives

27 May 2018

1 reference

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Alkyl-fluorinated thymidine derivatives for imaging cell proliferation I. The in vitro evaluation of some alkyl-fluorinated thymidine derivatives.

27 May 2018

1 reference

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An extremely active catalyst for the Negishi cross-coupling reaction

16 August 2018

1 reference

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New methods for the synthesis of N-benzoylated uridine and thymidine derivatives; a convenient method for N-debenzoylation

16 August 2018

1 reference

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5-propynylpyrimidine nucleoside derivatives: rationally designed mechanism-based inactivators of thymidylate synthase

16 August 2018

1 reference

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The first general method for palladium-catalyzed Negishi cross-coupling of aryl and vinyl chlorides: use of commercially available Pd(P(t-Bu)(3))(2) as a catalyst

16 August 2018

1 reference

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Palladium-catalyzed cross-coupling of pyrrole anions with aryl chlorides, bromides, and iodides

16 August 2018

1 reference

12 December 2020

A Highly Active Catalyst for the Room-Temperature Amination and Suzuki Coupling of Aryl Chlorides

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12 December 2020

Nucleosides. 136. Synthesis and antiviral effects of several 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-alkyluracils. Some structure-activity relationships

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12 December 2020

Rational design of selective antimetabolites of DNA-thymine biosynthesis: 5-propynylpyrimidine nucleoside derivatives

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12 December 2020

General method for the expedient synthesis of salt-free diorganozinc reagents using zinc methoxide

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12 December 2020

Investigations on the Suzuki-Miyaura and Negishi couplings with alkenyl phosphates: application to the synthesis of 1,1-disubstituted alkenes

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12 December 2020

Identifiers

DOI

10.1021/JO800444Y

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7 November 2017

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7 November 2017

PubMed publication ID

18522415

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