Total RNA sequencing reveals nascent transcription and widespread co-transcriptional splicing in the human brain (Q42772904)

7 November 2017

Total RNA sequencing reveals nascent transcription and widespread co-transcriptional splicing in the human brain (English)

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7 November 2017

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Ulf Gyllensten

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7 November 2017

Ammar Zaghlool

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7 November 2017

Jonatan Halvardson

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Anna Wetterbom

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Lucia Cavelier

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Lars Feuk

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7 November 2017

language of work or name

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6 November 2011

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Nature Structural & Molecular Biology

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1435-1440

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https://scigraph.springernature.com/pub.10.1038/nsmb.2143

7 November 2017

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Most "dark matter" transcripts are associated with known genes

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The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA

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A wave of nascent transcription on activated human genes

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Multiple links between transcription and splicing

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Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription.

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The intranuclear site of excision of each intron in Balbiani ring 3 pre-mRNA is influenced by the time remaining to transcription termination and different excision efficiencies for the various introns.

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22056773

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.2143

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Dimensions Publication ID

7 November 2017

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