Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. (Q42797662)

7 November 2017

Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. (English)

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7 November 2017

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7 November 2017

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7 November 2017

L Barberis

1

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7 November 2017

K K Wary

2

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7 November 2017

G Fiucci

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7 November 2017

F Liu

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7 November 2017

M Brancaccio

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7 November 2017

F Altruda

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7 November 2017

F G Giancotti

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7 November 2017

language of work or name

English

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publication date

1 November 2000

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Journal of Biological Chemistry

7 November 2017

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7 November 2017

275

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7 November 2017

36532-36540

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7 November 2017

47

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

7 November 2017

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The structural and mechanical complexity of cell-growth control

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Complexity and specificity of integrin signalling.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Integrin signalling and tyrosine phosphorylation: just the FAKs?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Src family kinases are required for integrin but not PDGFR signal transduction.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Focal adhesions, contractility, and signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Anchorage-dependent cell cycle progression

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Integrins, oncogenes, and anchorage independence.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Integrin signaling and cell growth control

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Regulation of the cell cycle by focal adhesion kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

p125FAK tyrosine phosphorylation and focal adhesion assembly: studies with phosphotyrosine phosphatase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Purification of fibronectin from human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Effects of cytochalasin, phalloidin, and pH on the elongation of actin filaments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Interaction of focal adhesion kinase with cytoskeletal protein talin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M002487200

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Identification of a Talin-binding Site in the Integrin β3Subunit Distinct from the NPLY Regulatory Motif of Post-ligand Binding Functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/mitogen-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

The association of CRKII with C3G can be regulated by integrins and defines a novel means to regulate the mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Extracellular matrix molecules and their receptors: functions in neural development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

Protein Kinase C Regulates Integrin-induced Activation of the Extracellular Regulated Kinase Pathway Upstream of Shc

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002487200

21 January 2018

Identifiers

DOI

10.1074/JBC.M002487200

1 reference

7 November 2017

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