The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. (Q42812980)

7 November 2017

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. (English)

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7 November 2017

Chou MM

1

1 reference

PubMed ID

8653792

7 November 2017

Blenis J

series ordinal

2

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PubMed ID

8653792

7 November 2017

language of work or name

English

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publication date

1 May 1996

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7 November 2017

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7 November 2017

85

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7 November 2017

4

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7 November 2017

573-583

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

7 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Parallel signal processing among mammalian MAPKs

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Structural and functional analysis of pp70S6k

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Isolation of a new human oncogene from a diffuse B-cell lymphoma.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

S6 phosphorylation and the p70s6k/p85s6k

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

p70s6k function is essential for G1 progression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

An essential role for Rac in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Nuclear localization of p85s6k: functional requirement for entry into S phase.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Thymic lymphoma induction by the AKT8 murine retrovirus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Rho family GTPases bind to phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Integration of MAP kinase signal transduction pathways at the serum response element

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981257-X

7 January 2021

10.1016/S0092-8674(00)81257-X

Identifiers

DOI

1 reference

7 November 2017

1 reference

PubMed ID

8653792