Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit (Q42813355)

7 November 2017

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit (English)

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7 November 2017

Tung O Chan

1

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7 November 2017

Ulrich Rodeck

2

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7 November 2017

Andrew M Chan

3

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7 November 2017

Alec C Kimmelman

4

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7 November 2017

Susan E Rittenhouse

5

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7 November 2017

George Panayotou

6

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7 November 2017

Philip N Tsichlis

7

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7 November 2017

1 March 2002

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7 November 2017

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7 November 2017

1

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7 November 2017

2

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7 November 2017

181-191

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Akt activation by growth factors is a multiple-step process: the role of the PH domain

7 November 2017

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

A human oncogene of the RAS superfamily unmasked by expression cDNA cloning

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Integrin-mediated signals regulated by members of the rho family of GTPases

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Disruption of epithelial cell-matrix interactions induces apoptosis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Phosphatidylinositol kinase activity associates with viral p60src protein

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformation

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

A direct interaction between oncogenic Ha-Ras and phosphatidylinositol 3-kinase is not required for Ha-Ras-dependent transformation of epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Modular peptide recognition domains in eukaryotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Binding of a diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor beta induces oligomerization of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Anti-apoptotic function of Rac in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

The role of phosphoinositide 3-kinase lipid products in cell function

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Rho family GTPases bind to phosphoinositide kinases

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Multiple Ras functions can contribute to mammalian cell transformation

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

Structure and function of phosphoinositide 3-kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900033-8

7 January 2021

10.1016/S1535-6108(02)00033-8

Identifiers

DOI

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7 November 2017

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