Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes. (Q42814165)

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23 January 2020

title

Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes (English)

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23 January 2020

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3

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23 January 2020

Shi-Xiong Tan

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ORCID Public Data File 2021

author name string

Shixiong Tan

series ordinal

1

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23 January 2020

Yvonne Ng

series ordinal

2

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23 January 2020

language of work or name

English

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publication date

1 April 2011

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23 January 2020

number of pages

6

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based on heuristic

inferred from page(s)

published in

Biochemical Journal

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23 January 2020

volume

435

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23 January 2020

issue

2

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23 January 2020

page(s)

539-544

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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

23 January 2020

cites work

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

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Role of Akt/protein kinase B in metabolism.

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Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

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Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane

21 January 2018

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Akt inhibitors reduce glucose uptake independently of their effects on Akt.

21 January 2018

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Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

21 January 2018

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MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

21 January 2018

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Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway

21 January 2018

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Hyperosmolarity reduces GLUT4 endocytosis and increases its exocytosis from a VAMP2-independent pool in l6 muscle cells

21 January 2018

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Expression of human glucose transporters in Xenopus oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms

21 January 2018

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GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer

21 January 2018

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The Akt kinases: isoform specificity in metabolism and cancer

21 January 2018

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Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 January 2018

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Akt kinases in breast cancer and the results of adjuvant therapy

21 January 2018

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

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AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

21 January 2018

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Deregulated Akt3 activity promotes development of malignant melanoma

21 January 2018

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Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20110040

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21348862%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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