Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells (Q42817431)

7 November 2017

Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells (English)

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7 November 2017

Julien Mazières

1

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7 November 2017

Vanessa Tillement

2

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7 November 2017

Cuider Allal

3

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7 November 2017

Carine Clanet

4

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7 November 2017

Lisbeth Bobin

5

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7 November 2017

Zhi Chen

6

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7 November 2017

Said M Sebti

7

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7 November 2017

Gilles Favre

8

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7 November 2017

Anne Pradines

9

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7 November 2017

language of work or name

English

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publication date

28 December 2004

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Experimental Cell Research

7 November 2017

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7 November 2017

304

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7 November 2017

2

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7 November 2017

354-364

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Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

7 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

Rho GTPases and signaling networks

7 January 2021

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Protein prenylation: molecular mechanisms and functional consequences

7 January 2021

1 reference

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Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation

7 January 2021

1 reference

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A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

7 January 2021

1 reference

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Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

7 January 2021

1 reference

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RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody

7 January 2021

1 reference

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Ultrastructural localization of ras-related proteins using epitope-tagged plasmids

7 January 2021

1 reference

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Intracellular localization of the P21rho proteins

7 January 2021

1 reference

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Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase

7 January 2021

1 reference

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Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

7 January 2021

1 reference

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RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation

7 January 2021

1 reference

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EGF modulation of the ras-related rhoB gene expression in human breast-cancer cell lines

7 January 2021

1 reference

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7 January 2021

1 reference

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7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity

7 January 2021

1 reference

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Increasing complexity of Ras signaling.

7 January 2021

1 reference

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Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

7 January 2021

1 reference

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Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB

7 January 2021

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7 January 2021

1 reference

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RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

7 January 2021

1 reference

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Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

7 January 2021

1 reference

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7 January 2021

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An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

7 January 2021

1 reference

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Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

7 January 2021

1 reference

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An essential role for Rac in Ras transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

A role for Rho in Ras transformation

7 January 2021

1 reference

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Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

Prenylation of RhoB is required for its cell transforming function but not its ability to activate serum response element-dependent transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

Loss of RhoB expression in human lung cancer progression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

7 January 2021

1 reference

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Improved oligonucleotide uptake and stability by a new drug carrier, the SupraMolecular Bio Vector (SMBV).

7 January 2021

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New colorimetric cytotoxicity assay for anticancer-drug screening

7 January 2021

1 reference

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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

7 January 2021

1 reference

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Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

7 January 2021

1 reference

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Reduction of caveolin and caveolae in oncogenically transformed cells

7 January 2021

1 reference

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Reduction of caveolin 1 gene expression in lung carcinoma cell lines

7 January 2021

1 reference

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Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

7 January 2021

1 reference

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RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

7 January 2021

1 reference

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RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development

7 January 2021

1 reference

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

7 January 2021

1 reference

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GTPase RhoB: an early predictor of neuronal death after transient focal ischemia in mice

7 January 2021

1 reference

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RhoB and the cellular response to farnesyltransferase inhibitors: the search for clues to cell death mechanisms

7 January 2021

1 reference

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Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

7 January 2021

1 reference

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Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors

7 January 2021

1 reference

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Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase

7 January 2021

1 reference

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Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1

7 January 2021

1 reference

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Role of isoprenoid lipids on the heterotrimeric G protein gamma subunit in determining effector activation

7 January 2021

1 reference

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Gbetagamma affinity for bovine rhodopsin is determined by the carboxyl-terminal sequences of the gamma subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.10.019

10.1016/J.YEXCR.2004.10.019

7 January 2021

Identifiers

DOI

1 reference

release_3pj2hek26zfkbdvulxtlemlrxy

7 November 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/3pj2hek26zfkbdvulxtlemlrxy

mapped directly with Wikidata item

24 November 2022

based on heuristic

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