Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK). (Q42824083)

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scientific article published on December 1998

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English	Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).	scientific article published on December 1998

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scholarly article

1 reference

Europe PubMed Central

8 November 2017

Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK). (English)

1 reference

Europe PubMed Central

8 November 2017

author name string

T Zhu

1

1 reference

Europe PubMed Central

8 November 2017

E L Goh

2

1 reference

Europe PubMed Central

8 November 2017

D LeRoith

3

1 reference

Europe PubMed Central

8 November 2017

P E Lobie

4

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Europe PubMed Central

8 November 2017

language of work or name

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publication date

1 December 1998

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Europe PubMed Central

8 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

8 November 2017

273

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Europe PubMed Central

8 November 2017

50

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Europe PubMed Central

8 November 2017

33864-33875

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Europe PubMed Central

8 November 2017

Mode of action of pituitary growth hormone on target cells

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21 January 2018

Molecular mechanism of growth hormone action

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21 January 2018

Signaling through the hematopoietic cytokine receptors.

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

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CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

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Integrin signalling and tyrosine phosphorylation: just the FAKs?

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Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription

1 reference

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Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G.

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Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk.

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Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton

1 reference

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Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

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21 January 2018

Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk

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Structures of Src-family tyrosine kinases

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Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

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Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes

1 reference

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Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

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Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

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Tensin: a potential link between the cytoskeleton and signal transduction

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c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

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p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

1 reference

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Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

1 reference

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NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

1 reference

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21 January 2018

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

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21 January 2018

Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2

1 reference

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21 January 2018

The Proto-oncogene Product c-Crk Associates with Insulin Receptor Substrate-1 and 4PS

1 reference

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21 January 2018

Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase

1 reference

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Prolactin stimulates the JAK2 and focal adhesion kinase pathways in human breast carcinoma T47-D cells

1 reference

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21 January 2018

Activation of phosphatidylinositol 3-kinase by prolactin in Nb2 cells

1 reference

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Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

1 reference

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21 January 2018

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

1 reference

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21 January 2018

Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

1 reference

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21 January 2018

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

1 reference

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21 January 2018

Requirements for localization of p130cas to focal adhesions

1 reference

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21 January 2018

Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase

1 reference

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21 January 2018

Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases

1 reference

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21 January 2018

The c-Jun transcription factor--bipotential mediator of neuronal death, survival and regeneration

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Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.

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Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells

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Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling

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The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

1 reference

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A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions

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SH3 domain of Bruton's tyrosine kinase can bind to proline-rich peptides of TH domain of the kinase and p120cbl

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Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

1 reference

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The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors

1 reference

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Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells

1 reference

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Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells

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Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling

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Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase

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A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components

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Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling

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Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association

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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

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21 January 2018

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10.1074/JBC.273.50.33864

1 reference

Europe PubMed Central

8 November 2017

1 reference

Europe PubMed Central

8 November 2017

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