Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis (Q42833059)

8 November 2017

title

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis (English)

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8 November 2017

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Tzippi Hershko

1

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8 November 2017

Doron Ginsberg

series ordinal

2

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8 November 2017

language of work or name

English

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publication date

18 December 2003

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Journal of Biological Chemistry

8 November 2017

published in

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8 November 2017

volume

279

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8 November 2017

issue

10

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8 November 2017

page(s)

8627-8634

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8 November 2017

cites work

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E2F1 pathways to apoptosis

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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

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p14ARF links the tumour suppressors RB and p53.

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

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Role of the p53-homologue p73 in E2F1-induced apoptosis

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Apaf-1 is a transcriptional target for E2F and p53

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Apaf-1 is a mediator of E2F-1-induced apoptosis

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Direct coupling of the cell cycle and cell death machinery by E2F.

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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ATM is a target for positive regulation by E2F-1.

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E2F and Ras Synergize in Transcriptionally Activating p14ARFExpression

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PUMA induces the rapid apoptosis of colorectal cancer cells

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

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Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1

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CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

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Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis

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Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein

21 January 2018

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E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

21 January 2018

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Gene expression changes in response to E2F1 activation.

21 January 2018

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Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells

21 January 2018

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Direct repression of the Mcl-1 promoter by E2F1.

21 January 2018

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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M312866200

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8 November 2017

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