Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells. (Q42833424)

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21 December 2019

title

Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells (English)

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21 December 2019

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6

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21 December 2019

Juan Carlos Lacal

7

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21 December 2019

Ana Ramírez De Molina

2

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21 December 2019

author name string

Agustín Rodríguez-González

1

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21 December 2019

Félix Fernández

3

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21 December 2019

Maria Angeles Ramos

4

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21 December 2019

Maria del Carmen Núñez

5

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21 December 2019

language of work or name

English

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publication date

1 December 2003

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21 December 2019

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21 December 2019

volume

22

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21 December 2019

issue

55

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21 December 2019

page(s)

8803-8812

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207062

21 December 2019

exact match

0 references

cites work

The inhibition of brain choline kinase by hemicholinium-3.

1 reference

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ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate

21 January 2018

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Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation.

21 January 2018

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Choline phosphate and phorbol ester potentiate the mitogenic effect of insulin by competitive mechanisms in NIH 3T3 fibroblasts

21 January 2018

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Regulation of mammalian cell membrane biosynthesis

21 January 2018

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Metalloselenonein, the selenium analogue of metallothionein: synthesis and characterization of its complex with copper ions

21 January 2018

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Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers

21 January 2018

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Cellular responses to excess phospholipid

21 January 2018

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7 January 2021

Structure-activity aspects of hemicholinium-3 (HC-3) and its analogs and congeners

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7 January 2021

Oncogenes and signal transduction

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Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I.

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7 January 2021

In vivo 31P MRS of experimental tumours

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

Emerging uses for genomic information in drug discovery

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7 January 2021

Pharmaceutical research in molecular oncology

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7 January 2021

Determination of cell number in monolayer cultures

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7 January 2021

Choline kinase inhibitors as a novel approach for antiproliferative drug design

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7 January 2021

Phosphorylation and regulation of choline kinase from Saccharomyces cerevisiae by protein kinase A

1 reference

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7 January 2021

Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism

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7 January 2021

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

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7 January 2021

Oncogenic conversion by regulatory changes in transcription factors

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7 January 2021

Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown

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7 January 2021

Ha-ras-transformation alters the metabolism of phosphatidylethanolamine and phosphatidylcholine in NIH 3T3 fibroblasts

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7 January 2021

Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy

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7 January 2021

Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K

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7 January 2021

Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.

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7 January 2021

Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines

1 reference

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7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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7 January 2021

Phospholipid metabolites, prognosis and proliferation in human breast carcinoma

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7 January 2021

Stimulation of phospholipid synthesis in HeLa cells by epidermal growth factor and insulin: activation of choline kinase and glycerophosphate acyltransferase

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7 January 2021

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

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7 January 2021

N-[2-bromocinnamyl(amino)ethyl]-5-isoquinolinesulphonamide (H-89) inhibits incorporation of choline into phosphatidylcholine via inhibition of choline kinase and has no effect on the phosphorylation of CTP:phosphocholine cytidylyltransferase

1 reference

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7 January 2021

Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207062

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14654777%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

21 December 2019

1052571926

0 references

Fatcat ID

release_iuisjfmmpfa6hifalcz5xakgm4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/iuisjfmmpfa6hifalcz5xakgm4

24 November 2022

mapped directly with Wikidata item

1 reference