Use and properties of ROCK-specific inhibitor Y-27632. (Q42834896)

8 November 2017

Use and properties of ROCK-specific inhibitor Y-27632. (English)

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8 November 2017

Narumiya S

1

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8 November 2017

Ishizaki T

series ordinal

2

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8 November 2017

Uehata M

series ordinal

3

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8 November 2017

language of work or name

English

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publication date

1 January 2000

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8 November 2017

Methods in Enzymology

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8 November 2017

325

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8 November 2017

273-284

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The small GTPase Rho: cellular functions and signal transduction

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Rho GTPases and signaling networks

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A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

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Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

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ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

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Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

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Identification of a putative target for Rho as the serine-threonine kinase protein kinase N

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Role of citron kinase as a target of the small GTPase Rho in cytokinesis.

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p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

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Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7

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Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

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The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

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p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions

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Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

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Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

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Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

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Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

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Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation

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A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea

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Regulation of Ca2+-independent smooth muscle contraction by alternative staurosporine-sensitive kinase.

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Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells

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Transformation mediated by RhoA requires activity of ROCK kinases

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Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

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Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase

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Rho GTPases control polarity, protrusion, and adhesion during cell movement

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The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes--possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy.

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7 January 2021

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

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Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

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Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change

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An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

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Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration

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An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

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Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration

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Rho Controls Cortical F-actin Disassembly in Addition to, but Independently of, Secretion in Mast Cells

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ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1

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Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells

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Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.

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p160ROCK mediates RhoA activation of Na-H exchange

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The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle

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7 January 2021

Relaxation of contracted rabbit tracheal and human bronchial smooth muscle by Y-27632 through inhibition of Ca2+ sensitization

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7 January 2021

10.1016/S0076-6879(00)25449-9

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DOI

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8 November 2017

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