DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer. (Q42836618)

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15 January 2020

title

DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer (English)

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15 January 2020

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Katy Bernard

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Laurence Danober

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Jean-Yves Thomas

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Cécile Lebrun

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Carmen Muñoz

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Alex Cordi

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Patrice Desos

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Pierre Lestage

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Philippe Morain

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publication date

1 October 2010

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CNS Neuroscience & Therapeutics

15 January 2020

published in

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volume

16

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issue

5

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page(s)

e193-212

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Human memory and the cholinergic system. A relationship to aging?

15 January 2020

cites work

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Crossref

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Miniature synaptic events maintain dendritic spines via AMPA receptor activation

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Aniracetam, 1-BCP and cyclothiazide differentially modulate the function of NMDA and AMPA receptors mediating enhancement of noradrenaline release in rat hippocampal slices

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Characterization of a new AMPA receptor radioligand, [3H]2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid

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Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

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Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium

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The chemokine growth-related gene product beta protects rat cerebellar granule cells from apoptotic cell death through alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors.

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(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices

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Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats

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Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator

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The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42.

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Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine CX516 in elderly participants with mild cognitive impairment: a progress report

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An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study

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Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory

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Hippocampal lesions and discrimination performance of mice in the radial maze: Sparing or impairment depending on the representational demands of the task

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Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain

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LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease.

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Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease

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Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis

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The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys.

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S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat.

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Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity

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Excitatory amino acids and memory: evidence from research on Alzheimer's disease and behavioral pharmacology

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12 December 2020

Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat.

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Long-term potentiation is impaired in middle-aged rats: regional specificity and reversal by adenosine receptor antagonists.

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Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates

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Spatial memory deficits in middle-aged mice correlate with lower exploratory activity and a subordinate status: role of hippocampal neurotrophins

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AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice.

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Therapeutic potential of positive AMPA receptor modulators in the treatment of neuropsychiatric disorders

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Noradrenergic and locus coeruleus modulation of the perforant path-evoked potential in rat dentate gyrus supports a role for the locus coeruleus in attentional and memorial processes

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Ampakines and the threefold path to cognitive enhancement

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The correlative triad among aging, dopamine, and cognition: current status and future prospects

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Learning induces long-term potentiation in the hippocampus

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Recent advances in positive allosteric modulators of the AMPA receptor.

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Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers

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Abnormal neurotransmitter release underlying behavioral and cognitive disorders: toward concepts of dynamic and function-specific dysregulation

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Microglia derived from aging mice exhibit an altered inflammatory profile.

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12 December 2020

Regulatory mechanisms of AMPA receptors in synaptic plasticity

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12 December 2020

S18986: a positive modulator of AMPA-receptors enhances (S)-AMPA-mediated BDNF mRNA and protein expression in rat primary cortical neuronal cultures

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12 December 2020

AMPA receptor potentiators as cognitive enhancers

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12 December 2020

Amyloid beta-peptide Abeta(1-42) but not Abeta(1-40) attenuates synaptic AMPA receptor function

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12 December 2020

Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil

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12 December 2020

AMPA potentiator treatment of cognitive deficits in Alzheimer disease

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12 December 2020

AMPA receptor potentiators: application for depression and Parkinson's disease

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12 December 2020

Comparison of single vs. multiple administrations of the AMPA receptors modulator S 18986 in the object recognition task in rats

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12 December 2020

Ampakine (CX717) effects on performance and alertness during simulated night shift work

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12 December 2020

Behavioral and biological effects of chronic S18986, a positive AMPA receptor modulator, during aging

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12 December 2020

The AMPA modulator S 18986 improves declarative and working memory performances in aged mice

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A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

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Cyclothiazide selectively potentiates AMPA- and kainate-induced [3H]norepinephrine release from rat hippocampal slices.

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Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists

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Facilitation of glutamate receptors enhances memory

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10.1111/J.1755-5949.2009.00088.X

Identifiers

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PubMed publication ID

21050420

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