Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice (Q42947038)

11 November 2017

Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice (English)

1 reference

11 November 2017

Y Takahashi

1

1 reference

11 November 2017

D M Cerasoli

2

1 reference

11 November 2017

J M Dal Porto

3

1 reference

11 November 2017

M Shimoda

4

1 reference

11 November 2017

R Freund

5

1 reference

11 November 2017

W Fang

6

1 reference

11 November 2017

D G Telander

7

1 reference

11 November 2017

E N Malvey

8

1 reference

11 November 2017

D L Mueller

9

1 reference

11 November 2017

T W Behrens

10

1 reference

11 November 2017

G Kelsoe

11

1 reference

11 November 2017

language of work or name

English

0 references

publication date

1 August 1999

1 reference

Journal of Experimental Medicine

11 November 2017

1 reference

11 November 2017

190

1 reference

11 November 2017

3

1 reference

11 November 2017

399-410

1 reference

Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.

11 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Visualization of specific B and T lymphocyte interactions in the lymph node.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Humoral immunity due to long-lived plasma cells.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Immunization with immune complex alters the repertoire of antigen-reactive B cells in the germinal centers

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. Anti-Ig down-regulates Fas expression of CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Role of bcl-X(L) in the control of apoptosis in murine myeloma cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

In situ studies of the germinal center reaction

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Immunohistochemical analysis of in vivo patterns of Bcl-X expression

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Antigen-induced B-cell death and elimination during germinal-centre immune responses

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

The Follicular Dendritic Cell: Long Term Antigen Retention During Immunity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Cell Selection by Antigen in the Immune Response

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

B-cell memory is short-lived in the absence of antigen.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

The role of somatic hypermutation in the generation of antibody diversity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Maintenance of B-cell memory by long-lived cells generated from proliferating precursors

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Intraclonal generation of antibody mutants in germinal centres

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Most peripheral B cells in mice are ligand selected

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Maturation of the immune response in germinal centers

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Prolonged antigen half-life in the lymphoid follicles of specifically immunized mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

ANTIGENS IN IMMUNITY. IV. CELLULAR LOCALIZATION OF 125-I- AND 131-I-LABELLED FLAGELLA IN LYMPH NODES

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Survival of long-lived plasma cells is independent of antigen.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Dependence of germinal center B cells on expression of CD21/CD35 for survival.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195593

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

16 August 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.3.399

Mechanism of antigen-driven selection in germinal centres

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.3.399

VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.3.399

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.3.399

Expression of bcl-x during mouse B cell differentiation and following activation by various stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.3.399

Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.3.399

Alternative pathways for the selection of antigen-specific peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.3.399

V(D)J recombinase activity in a subset of germinal center B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.3.399

Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10430628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10430628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.190.3.399

1 reference

11 November 2017

1 reference

11 November 2017

1 reference