Rational design and functional expression of a constitutively active single-chain NS4A-NS3 proteinase (Q42991702)

12 November 2017

Rational design and functional expression of a constitutively active single-chain NS4A-NS3 proteinase (English)

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12 November 2017

Raffaele De Francesco

8

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12 November 2017

7

Tramontano A

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12 November 2017

Pasquo A

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12 November 2017

Nardi MC

2

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12 November 2017

Dimasi N

3

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12 November 2017

Tomei L

4

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12 November 2017

Steinkühler C

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12 November 2017

Delmastro P

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12 November 2017

language of work or name

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1 January 1998

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12 November 2017

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12 November 2017

3

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12 November 2017

6

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12 November 2017

433-441

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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

12 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Hepatitis C and hepatocellular carcinoma

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Molecular virology of hepatitis C virus

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

A second hepatitis C virus-encoded proteinase

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Analysis of NS3-mediated processing of the hepatitis C virus non-structural region in vitro

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Processing of hepatitis C viral polyprotein in Escherichia coli

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Biosynthesis and biochemical properties of the hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

In vitro study of the NS2-3 protease of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Kinetic and structural analyses of hepatitis C virus polyprotein processing

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Identification of the domain required for trans-cleavage activity of hepatitis C viral serine proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Identification of the protease domain in NS3 of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Serine protease of hepatitis C virus expressed in insect cells as the NS3/4A complex.

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: identification of sequence and critical residues of NS4A for the cofactor activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

A zinc binding site in viral serine proteinases

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Redesigning the substrate specificity of the hepatitis C virus NS3 protease.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Analysis and prediction of the different types of beta-turn in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

The N-end rule: functions, mysteries, uses

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Characterisation of an HCV NS3/NS4A proteinase fusion protein expressed in E.coli using synthetic peptide substrates

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Expression of a hepatitis C virus NS3 protease-NS4A fusion protein in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

WHAT IF: a molecular modeling and drug design program

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Product inhibition of the hepatitis C virus NS3 protease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

Use of T7 RNA polymerase to direct expression of cloned genes

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https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

High-level expression of soluble protein in Escherichia coli using a His6-tag and maltose-binding-protein double-affinity fusion system.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2898%2900060-1

7 January 2021

10.1016/S1359-0278(98)00060-1

Identifiers

DOI

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12 November 2017

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